GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice

Irene Delgado, Manuel Carrasco, Elena Cano, Rita Carmona, Rocío García‐Carbonero, Luis M. Marín‐Gómez, Bernat Soria, Francisco Martín, David A. Cano, Ramón Muñoz‐Chápuli, Anabel Rojas – 10 January 2014 – The zinc finger transcription factor GATA4 controls specification and differentiation of multiple cell types during embryonic development. In mouse embryonic liver, Gata4 is expressed in the endodermal hepatic bud and in the adjacent mesenchyme of the septum transversum. Previous studies have shown that Gata4 inactivation impairs liver formation.

Ethnic disparities and liver transplantation rates in hepatocellular carcinoma patients in the recent era: Results from the surveillance, epidemiology, and end results registry

Robert J. Wong, Pardha Devaki, Long Nguyen, Ramsey Cheung, Mindie H. Nguyen – 10 January 2014 – Hepatocellular carcinoma (HCC) is a leading cause of morbidity and mortality. After the implementation of the Model for End‐Stage Liver Disease system, rates of liver transplantation (LT) for HCC patients increased. However, it is not clear whether this trend has continued into recent times. Using the Surveillance, Epidemiology, and End Results registry (1998‐2010), we retrospectively analyzed trends for LT among HCC patients in 3 time periods: 1998‐2003, 2004‐2008, and 2009‐2010.

Single‐center experience and long‐term outcomes of duct‐to‐duct biliary reconstruction in infantile living donor liver transplantation

Hidekazu Yamamoto, Shintaro Hayashida, Katsuhiro Asonuma, Masaki Honda, Hiroko Suda, Takahiro Murokawa, Yuki Ohya, Kwang‐Jong Lee, Takayuki Takeichi, Yukihiro Inomata – 10 January 2014 – The indications for duct‐to‐duct (DD) biliary reconstruction in living donor liver transplantation (LDLT) for small children are still controversial. In this study, the feasibility of DD biliary reconstruction versus Roux‐en‐Y (RY) biliary reconstruction was investigated in terms of long‐term outcomes.

Additive effect of pretransplant obesity, diabetes, and cardiovascular risk factors on outcomes after liver transplantation

Anna J. Dare, Lindsay D. Plank, Anthony R. J. Phillips, Edward J. Gane, Barry Harrison, David Orr, Yannan Jiang, Adam S. J. R. Bartlett – 7 January 2014 – The effects of pretransplant obesity, diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HTN) on outcomes after liver transplantation (LT) are controversial. Questions have also been raised about the appropriateness of the body mass index (BMI) for assessing obesity in patients with end‐stage liver disease. Both issues have implications for organ allocation in LT.

Insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma

Tony Gutschner, Monika Hämmerle, Nikolaos Pazaitis, Nadine Bley, Evgenij Fiskin, Hannah Uckelmann, Andreas Heim, Matthias Groβ, Nina Hofmann, Robert Geffers, Britta Skawran, Thomas Longerich, Kai Breuhahn, Peter Schirmacher, Britta Mühleck, Stefan Hüttelmaier, Sven Diederichs – 7 January 2014 – Hepatocarcinogenesis is a stepwise process. It involves several genetic and epigenetic alterations, e.g., loss of tumor suppressor gene expression (TP53, PTEN, RB) as well as activation of oncogenes (c‐MYC, MET, BRAF, RAS).

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