Does the interferon‐lambda rather than the interferon‐alpha pathway determine the outcome of hepatitis C virus infection?
Sabine Mihm, Ulrich Spengler, Ahmad Amanzada, Giuliano Ramadori – 31 July 2014
Mutational landscape of hepatoblastoma goes beyond the Wnt‐β‐catenin pathway
Ze‐Guang Han – 31 July 2014
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
Franziska S. Hoffmann, Andreas Schmidt, Meike Dittmann Chevillotte, Christian Wisskirchen, Johannes Hellmuth, Simone Willms, Rachel H. Gilmore, Jürgen Glas, Matthias Folwaczny, Tobias Müller, Thomas Berg, Ulrich Spengler, Karen Fitzmaurice, Dermot Kelleher, Nicole Reisch, Charles M. Rice, Stefan Endres, Simon Rothenfusser – 30 July 2014
Clinical outcomes of hepatitis B virus coinfection in a United States cohort of hepatitis C virus‐infected patients
Robert L. Kruse, Jennifer R. Kramer, Gia L. Tyson, Zhigang Duan, Liang Chen, Hashem B. El‐Serag, Fasiha Kanwal – 28 July 2014 – The effect of hepatitis B virus (HBV) coinfection in patients with hepatitis C virus (HCV) remains unclear. We used the National Veterans Affairs HCV Clinical Case Registry to identify patients with confirmed HCV viremia during 1997‐2005. We defined HBV coinfection as a positive test for hepatitis B surface antigen, HBV DNA, or hepatitis B e antigen.
Liver and gender: Are there differences in fibrous tissue before the onset of fibrosis?
Ricardo Marcos, Carla Correia‐Gomes – 28 July 2014
Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation
Johanna Hynynen, Tuomas Komulainen, Eija Tukiainen, Arno Nordin, Johanna Arola, Reetta Kälviäinen, Leena Jutila, Matias Röyttä, Reetta Hinttala, Kari Majamaa, Heikki Mäkisalo, Johanna Uusimaa – 28 July 2014 – Patients with mutations in the POLG1 gene encoding mitochondrial DNA polymerase gamma have an increased risk of valproate‐induced liver failure. POLG1 mutations are common, and these patients often suffer from intractable seizures. The role of liver transplantation in the treatment of patients with mitochondrial diseases has been controversial.
Global distribution and prevalence of hepatitis C virus genotypes
Jane P. Messina, Isla Humphreys, Abraham Flaxman, Anthony Brown, Graham S. Cooke, Oliver G. Pybus, Eleanor Barnes – 28 July 2014 – Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends.
Global distribution and prevalence of hepatitis C virus genotypes
Jane P. Messina, Isla Humphreys, Abraham Flaxman, Anthony Brown, Graham S. Cooke, Oliver G. Pybus, Eleanor Barnes – 28 July 2014 – Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends.
T‐cell immunoglobulin and mucin domain 4 (TIM‐4) signaling in innate immune‐mediated liver ischemia‐reperfusion injury
Haofeng Ji, Yuanxing Liu, Yu Zhang, Xiu‐da Shen, Feng Gao, Ronald W. Busuttil, Vijay K. Kuchroo, Jerzy W. Kupiec‐Weglinski – 28 July 2014
Costs of telaprevir‐based triple therapy for hepatitis C: $189,000 per sustained virological response
Kian Bichoupan, Valerie Martel‐Laferriere, David Sachs, Michel Ng, Emily A. Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, Ponni V. Perumalswami, Thomas D. Schiano, Joseph A. Odin, Lawrence Liu, Alan J. Moskowitz, Douglas T. Dieterich, Andrea D.