Laura Milazzo, Anna Maria Peri, Lucia Lodi, Guido Gubertini, Anna Lisa Ridolfo, Spinello Antinori – 21 January 2014 – Primary intestinal lymphangiectasia (PIL) is a protein‐losing enteropathy characterized by tortuous and dilated lymph channels of the small bowel. The main symptoms are bilateral lower limb edema, serosal effusions, and vitamin D malabsorption resulting in osteoporosis. We report here a case of long‐lasting misdiagnosed PIL with a peculiar liver picture, characterized by a very high stiffness value at transient elastography, which decreased with clinical improvement.

Nils Jedicke, Nina Struever, Nupur Aggrawal, Tobias Welte, Michael P. Manns, Nisar P. Malek, Lars Zender, Sabina Janciauskiene, Torsten Wuestefeld – 21 January 2014 – Acute liver failure remains a critical clinical condition, with high mortality rates, and increased apoptosis of hepatocytes represents a key event in the cause of liver failure. Alpha‐1‐antitrypsin (AAT) is synthesized and secreted mainly by hepatocytes, and plasma purified AAT is used for augmentation therapy in patients with AAT deficiency.

Ben Zhou, Yi Zhang, Fang Zhang, Yulei Xia, Jun Liu, Rui Huang, Yuangao Wang, Yanan Hu, Jingxia Wu, Changgui Dai, Hui Wang, Yanyang Tu, Xiaozhong Peng, Yiqian Wang, Qiwei Zhai – 18 January 2014 – The protein deacetylase, sirtuin 1 (SIRT1), involved in regulating hepatic insulin sensitivity, shows circadian oscillation and regulates the circadian clock. Recent studies show that circadian misalignment leads to insulin resistance (IR); however, the underlying mechanisms are largely unknown.

Teresa Santantonio, Massimo Fasano, Evangelista Sagnelli, Paolo Tundo, Sergio Babudieri, Paolo Fabris, Mario Toti, Giovanni Perri, Nicoletta Marino, Eligio Pizzigallo, Gioacchino Angarano, the Acute Hepatitis C Study Group – 18 January 2014 – Therapy of acute hepatitis C (AHC) has not yet been standardized and several issues are still unresolved. This open, randomized, multicenter trial aimed to assess the efficacy and safety of a 24‐week course of pegylated IFN (Peg‐IFN) alpha‐2b versus a 12‐week course of Peg‐IFN alpha‐2b alone or with ribavirin (RBV) in AHC patients.

Keiichi Shirasaki, Keiko Taguchi, Michiaki Unno, Hozumi Motohashi, Masayuki Yamamoto – 17 January 2014 – Hepatectomy is a standard therapy that allows liver cancer patients to achieve long‐term survival. Preceding hepatectomy, portal vein embolization (PVE) is frequently performed to increase the remnant liver size and reduce complications. Although the clinical importance of PVE is widely accepted, molecular mechanisms by which PVE leads to compensatory hypertrophy of nonembolized lobes remain elusive.

Krasimira Aleksandrova, Heiner Boeing, Ute Nöthlings, Mazda Jenab, Veronika Fedirko, Rudolf Kaaks, Annekatrin Lukanova, Antonia Trichopoulou, Dimitrios Trichopoulos, Paolo Boffetta, Elisabeth Trepo, Sabine Westhpal, Talita Duarte‐Salles, Magdalena Stepien, Kim Overvad, Anne Tjønneland, Jytte Halkjær, Marie‐Christine Boutron‐Ruault, Laure Dossus, Antoine Racine, Pagona Lagiou, Christina Bamia, Vassiliki Benetou, Claudia Agnoli, Domenico Palli, Salvatore Panico, Rosario Tumino, Paolo Vineis, Bas Bueno‐de‐Mesquita, Petra H. Peeters, Inger Torhild Gram, Eiliv Lund, Elisabete Weiderpass, J.

Gabriel G. Malouf, Sylvie Job, Valérie Paradis, Monique Fabre, Laurence Brugières, Pierre Saintigny, Laure Vescovo, Jacques Belghiti, Sophie Branchereau, Sandrine Faivre, Aurélien Reyniès, Eric Raymond – 17 January 2014 – Fibrolamellar hepatocellular carcinoma (FLC) is a rare subtype of liver cancer occurring mostly in children and young adults. We have shown that FLC comprises two separate entities: pure (p‐FLC) and mixed‐FLC (m‐FLC), differing in clinical presentation and course.

Ling Yang, Ekihiro Seki – 17 January 2014

Chien‐Hsieh Chiang, Long‐Teng Lee, Shou‐Hung Hung, Wen‐Yuan Lin, Hui‐Fang Hung, Wei‐Shiung Yang, Pei‐Kun Sung, Kuo‐Chin Huang – 15 January 2014 – Limited data exist regarding metabolic risk factors for deaths from hepatocellular carcinoma (HCC) in aging individuals. We investigated the association between diabetes, dyslipidemia, and HCC mortality in those aged 40 years or more (middle‐aged and elderly).

Emeric Limagne, Vanessa Cottet, Alexia Karen Cotte, Samia Hamza, Patrick Hillon, Norbert Latruffe, Dominique Delmas, for the CiRCE Study Group – 15 January 2014