Outcomes after liver transplantation for patients with hepatocellular carcinoma and a low risk of dropout from the transplant waiting list
Neil Mehta, Jennifer L. Dodge, John Paul Roberts, Ryutaro Hirose, Francis Y. Yao – 3 February 2014
Conversion from twice daily tacrolimus capsules to once daily extended‐release tacrolimus (LCP‐Tacro): Phase 2 trial of stable liver transplant recipients
Rita R. Alloway, Devin E. Eckhoff, W. Kenneth Washburn, Lewis W. Teperman – 3 February 2014 – LCP‐Tacro is an extended‐release formulation of tacrolimus designed for once‐daily dosing. Studies in renal transplantation demonstrate greater bioavailability with similar safety and efficacy vs. twice‐daily tacrolimus capsules.
Long noncoding RNA in liver diseases
Kenji Takahashi, Irene Yan, Hiroaki Haga, Tushar Patel – 3 February 2014 – The identification of the presence of large RNA transcripts that do not code for proteins but that may have biological functions has provided an important new perspective in gene regulation. These long noncoding RNAs (lncRNAs) are being increasingly recognized to contribute to many biological processes through diverse mechanisms. The roles of these emerging genes are being recognized across kingdoms.
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury
Ingrid Lua, David James, Jiaohong Wang, Kasper S. Wang, Kinji Asahina – 1 February 2014 – Hepatic stellate cells (HSCs) and portal fibroblasts (PFs) are believed to be the major source of myofibroblasts that participate in fibrogenesis by way of synthesis of proinflammatory cytokines and extracellular matrices. Previous lineage tracing studies using MesP1Cre and Rosa26lacZflox mice demonstrated that MesP1+ mesoderm gives rise to mesothelial cells (MCs), which differentiate into HSCs and PFs during liver development.
Reply
Kristopher Croome, Roberto Hernandez‐Alejandro – 31 January 2014
Liver transplantation for alcoholic cirrhosis in Japan
Michael R. Lucey – 30 January 2014
Is the aerobic capacity at the time of cardiopulmonary exercise testing useful in predicting survival following liver transplantation?
Rebecca Young, Nick Murphy, Ahmed M. Elsharkawy – 30 January 2014
Effects of air embolism size and location on porcine hepatic microcirculation in machine perfusion
Maria‐Louisa Izamis, Andreas Efstathiades, Christina Keravnou, Soteria Georgiadou, Paulo N. Martins, Michalakis A. Averkiou – 30 January 2014 – The handling of donor organs frequently introduces air into the microvasculature, but little is known about the extent of the damage caused as a function of the embolism size and distribution. Here we introduced embolisms of different sizes into the portal vein, the hepatic artery, or both during the flushing stage of porcine liver procurement.
Statin therapy is associated with the development of new‐onset diabetes after transplantation in liver recipients with high fasting plasma glucose levels
Yongin Cho, Min Jung Lee, Eun Yeong Choe, Chang Hee Jung, Dong Jin Joo, Myoung Soo Kim, Bong Soo Cha, Joong‐Yeol Park, Eun Seok Kang – 30 January 2014 – New‐onset diabetes after transplantation (NODAT) and dyslipidemia are important metabolic complications after liver transplantation (LT) that can adversely affect both allograft and patient survival. Statins are used as first‐line therapies for dyslipidemia because of their effectiveness and safety profile. However, it has recently been reported that statin therapy is associated with new‐onset diabetes in the nontransplant population.