Diagnosis of sinusoidal obstruction syndrome by positron emission tomography/computed tomography: Report of two cases treated by defibrotide

Mathieu Gauthé, Laurence Bozec, Pierre Bedossa – 17 March 2014 – Sinusoidal obstruction syndrome (SOS) is a potentially fatal liver injury that mainly occurs after myeloablative chemotherapy. We report two cases of SOS investigated by 18F‐fluorodeoxyglucose positron emission tomography/computed tomography and treated with defibrotide. (Hepatology 2014;60:1789–1791)

Diagnosis of sinusoidal obstruction syndrome by positron emission tomography/computed tomography: Report of two cases treated by defibrotide

Mathieu Gauthé, Laurence Bozec, Pierre Bedossa – 17 March 2014 – Sinusoidal obstruction syndrome (SOS) is a potentially fatal liver injury that mainly occurs after myeloablative chemotherapy. We report two cases of SOS investigated by 18F‐fluorodeoxyglucose positron emission tomography/computed tomography and treated with defibrotide. (Hepatology 2014;60:1789–1791)

Epigenetics in liver disease

Derek A. Mann – 16 March 2014 – Epigenetics is a term that encompasses a variety of regulatory processes that are able to crosstalk in order to influence gene expression and cell phenotype in response to environmental cues. A deep understanding of epigenetics offers the potential for fresh insights into the basis for complex chronic diseases and improved diagnostic and prognostic tools.

Epigenetics in liver disease

Derek A. Mann – 16 March 2014 – Epigenetics is a term that encompasses a variety of regulatory processes that are able to crosstalk in order to influence gene expression and cell phenotype in response to environmental cues. A deep understanding of epigenetics offers the potential for fresh insights into the basis for complex chronic diseases and improved diagnostic and prognostic tools.

Activation of invariant natural killer T cells impedes liver regeneration by way of both IFN‐γ‐ and IL‐4‐dependent mechanisms

Shi Yin, Hua Wang, Adeline Bertola, Dechun Feng, Ming‐jiang Xu, Yan Wang, Bin Gao – 13 March 2014 – Invariant natural killer T (iNKT) cells are a major subset of lymphocytes found in the liver. These cells mediate various functions, including hepatic injury, fibrogenesis, and carcinogenesis. However, the function of iNKT cells in liver regeneration remains unclear. In the present study, partial hepatectomy (PHx) was used to study liver regeneration. α‐Galactosylceramide (α‐GalCer), a specific ligand for iNKT cells, was used to induce iNKT cell activation.

Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C

Konstantin Kazankov, Francisco Barrera, Holger Jon Møller, Bo Martin Bibby, Hendrik Vilstrup, Jacob George, Henning Grønbæk – 13 March 2014 – Macrophages are involved in inflammation and liver fibrosis and soluble (s)CD163 is a specific marker of activated macrophages. We investigated associations between sCD163 and biochemical and histological parameters of inflammatory activity and fibrosis in 551 patients with chronic hepatitis C virus (HCV) and 203 patients with chronic hepatitis B virus (HBV) before antiviral treatment.

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