E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr‐1/SHP/EID1 network

Yuxia Zhang, Ningyi Xu, Jun Xu, Bo Kong, Bryan Copple, Grace L. Guo, Li Wang – 11 March 2014 – E2F transcription factor 1 (E2F1) is an important regulator of metabolic diseases; however, its role in liver function remains elusive. This study unraveled a regulatory cascade involving E2F1, early growth response‐1 (Egr‐1), nuclear receptor small heterodimer partner (SHP, NR0B2), and EIA‐like inhibitor of differentiation 1 (EID1) in cholestatic liver fibrosis.

Angiotensin‐II type 1 receptor‐mediated Janus kinase 2 activation induces liver fibrosis

Michaela Granzow, Robert Schierwagen, Sabine Klein, Benita Kowallick, Sebastian Huss, Markus Linhart, Irela G. Reza Mazar, Jan Görtzen, Annabelle Vogt, Frank A. Schildberg, Maria A. Gonzalez‐Carmona, Alexandra Wojtalla, Benjamin Krämer, Jacob Nattermann, Sören V. Siegmund, Nikos Werner, Dieter O. Fürst, Wim Laleman, Percy Knolle, Vijay H. Shah, Tilman Sauerbruch, Jonel Trebicka – 11 March 2014 – Activation of the renin angiotensin system resulting in stimulation of angiotensin‐II (AngII) type I receptor (AT1R) is an important factor in the development of liver fibrosis.

C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression

Gui‐lian Xu, Jian Chen, Fei Yang, Gui‐qing Li, Li‐xin Zheng, Yu‐zhang Wu – 7 March 2014 – Viral fulminant hepatitis (FH) remains a serious clinical problem with very high mortality. Lacking understanding of FH pathogenesis has in essence hindered efficient clinical treatment. Inferring from a correlation observed between the genetic differences in the complement component 5 (C5) and the susceptibility of mouse strains to murine hepatitis virus strain‐3 (MHV‐3) infections, we propose that excessive complement activation plays a critical role in the development of FH.

The effect of anterograde persufflation on energy charge and hepatocyte function in donation after cardiac death livers unsuitable for transplant

Shirin Elizabeth Khorsandi, Suttiruk Jitraruch, Lynette Fairbanks, Corina Cotoi, Wayel Jassem, Hector Vilca‐Melendez, Andreas Prachalias, Anil Dhawan, Nigel Heaton, Parthi Srinivasan – 7 March 2014 – Donation after cardiac death (DCD) livers are considered to be marginal organs for solid organ and cell transplantation. Low energy charge (EC) and low purine quantity within the liver parenchyma has been associated with poor outcome after liver transplantation.

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