Angiotensin‐II type 1 receptor‐mediated Janus kinase 2 activation induces liver fibrosis

Michaela Granzow, Robert Schierwagen, Sabine Klein, Benita Kowallick, Sebastian Huss, Markus Linhart, Irela G. Reza Mazar, Jan Görtzen, Annabelle Vogt, Frank A. Schildberg, Maria A. Gonzalez‐Carmona, Alexandra Wojtalla, Benjamin Krämer, Jacob Nattermann, Sören V. Siegmund, Nikos Werner, Dieter O. Fürst, Wim Laleman, Percy Knolle, Vijay H. Shah, Tilman Sauerbruch, Jonel Trebicka – 11 March 2014 – Activation of the renin angiotensin system resulting in stimulation of angiotensin‐II (AngII) type I receptor (AT1R) is an important factor in the development of liver fibrosis.

E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr‐1/SHP/EID1 network

Yuxia Zhang, Ningyi Xu, Jun Xu, Bo Kong, Bryan Copple, Grace L. Guo, Li Wang – 11 March 2014 – E2F transcription factor 1 (E2F1) is an important regulator of metabolic diseases; however, its role in liver function remains elusive. This study unraveled a regulatory cascade involving E2F1, early growth response‐1 (Egr‐1), nuclear receptor small heterodimer partner (SHP, NR0B2), and EIA‐like inhibitor of differentiation 1 (EID1) in cholestatic liver fibrosis.

Identification of MicroRNA‐214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression

Dong‐liang Chen, Zhi‐qiang Wang, Zhao‐lei Zeng, Wen‐jing Wu, Dong‐sheng Zhang, Hui‐yan Luo, Feng Wang, Miao‐zhen Qiu, De‐shen Wang, Chao Ren, Feng‐hua Wang, Lucia J. Chiao, Helene Pelicano, Peng Huang, Yu‐hong Li, Rui‐hua Xu – 11 March 2014 – The purpose of this study was to identify microRNAs (miRNAs) involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their underlying mechanisms.

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