Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C

Konstantin Kazankov, Francisco Barrera, Holger Jon Møller, Bo Martin Bibby, Hendrik Vilstrup, Jacob George, Henning Grønbæk – 13 March 2014 – Macrophages are involved in inflammation and liver fibrosis and soluble (s)CD163 is a specific marker of activated macrophages. We investigated associations between sCD163 and biochemical and histological parameters of inflammatory activity and fibrosis in 551 patients with chronic hepatitis C virus (HCV) and 203 patients with chronic hepatitis B virus (HBV) before antiviral treatment.

Identification of MicroRNA‐214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression

Dong‐liang Chen, Zhi‐qiang Wang, Zhao‐lei Zeng, Wen‐jing Wu, Dong‐sheng Zhang, Hui‐yan Luo, Feng Wang, Miao‐zhen Qiu, De‐shen Wang, Chao Ren, Feng‐hua Wang, Lucia J. Chiao, Helene Pelicano, Peng Huang, Yu‐hong Li, Rui‐hua Xu – 11 March 2014 – The purpose of this study was to identify microRNAs (miRNAs) involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their underlying mechanisms.

E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr‐1/SHP/EID1 network

Yuxia Zhang, Ningyi Xu, Jun Xu, Bo Kong, Bryan Copple, Grace L. Guo, Li Wang – 11 March 2014 – E2F transcription factor 1 (E2F1) is an important regulator of metabolic diseases; however, its role in liver function remains elusive. This study unraveled a regulatory cascade involving E2F1, early growth response‐1 (Egr‐1), nuclear receptor small heterodimer partner (SHP, NR0B2), and EIA‐like inhibitor of differentiation 1 (EID1) in cholestatic liver fibrosis.

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