Antiretroviral therapy, interferon sensitivity, and virologic setpoint in human immunodeficiency virus/hepatitis C virus coinfected patients
Ashwin Balagopal, Abraham J. Kandathil, Yvonne H. Higgins, Jonathan Wood, Justin Richer, Jeffrey Quinn, Lois Eldred, Zhiping Li, Stuart C. Ray, Mark S. Sulkowski, David L. Thomas – 5 April 2014 – Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) cause substantial mortality, especially in persons chronically infected with both viruses. HIV infection raises plasma HCV RNA levels and diminishes the response to exogenous alpha interferon (IFN). The degree to which antiretroviral therapy (ART) control of infection overcomes these HIV effects is unknown.