Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

Pierre Bedossa, the FLIP Pathology Consortium – 19 April 2014 – Biopsy is still the gold standard for the diagnosis of nonalcoholic steatohepatitis but the definition may vary among pathologists, a drawback especially in evaluation of biopsies for clinical trials. We previously developed a scoring system (steatosis, activity, fibrosis [SAF]) allowing the use of an algorithm (fatty liver inhibition of progression [FLIP]) for the classification of liver injury in morbid obesity.

Hepatocyte nuclear factor 4α‐nuclear factor‐κB feedback circuit modulates liver cancer progression

Bei‐Fang Ning, Jin Ding, Jiao Liu, Chuan Yin, Wen‐Ping Xu, Wen‐Ming Cong, Qing Zhang, Fei Chen, Tao Han, Xing Deng, Pei‐Qin Wang, Cai‐Feng Jiang, Jun‐Ping Zhang, Xin Zhang, Hong‐Yang Wang, Wei‐Fen Xie – 18 April 2014 – Hepatocyte nuclear factor 4α (HNF4α) is a liver enriched transcription factor and is indispensable for liver development. However, the role of HNF4α in hepatocellular carcinoma (HCC) progression remains to be elucidated.

Saturated free fatty acids induce cholangiocyte lipoapoptosis

Sathish Kumar Natarajan, Sally A. Ingham, Ashley M. Mohr, Cody J. Wehrkamp, Anuttoma Ray, Sohini Roy, Sophie C. Cazanave, Mary Anne Phillippi, Justin L. Mott – 18 April 2014 – Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) with portal inflammation and ductular reaction. Based on reports of biliary damage, as well as increased circulating free fatty acids (FFAs) in NAFLD, we hypothesized the involvement of cholangiocyte lipoapoptosis as a mechanism of cellular injury.

Surgical site infections after liver retransplantation: Incidence and risk factors

Harshal Shah, Walter C. Hellinger, Michael G. Heckman, Nancy Diehl, Jefree A. Shalev, Darrin L. Willingham, C. Burcin Taner, Dana K. Perry, Justin Nguyen – 18 April 2014 – Surgical site infections (SSIs) after liver transplantation (LT) are associated with an increased risk of graft loss and death. The incidence of SSIs after LT and their risk factors have been determined for first LT but not for second LT. The importance of reporting the incidence of SSIs risk‐stratified by first LT versus second LT is not known.

Pilot study of high‐intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients wait‐listed for liver transplantation

Kenneth S. H. Chok, Tan To Cheung, Regina C. L. Lo, Ferdinand S. K. Chu, Simon H. Y. Tsang, Albert C. Y. Chan, William W. Sharr, James Y. Y. Fung, Wing Chiu Dai, See Ching Chan, Sheung Tat Fan, Chung Mau Lo – 18 April 2014 – The objective of this study was to investigate the outcomes of high‐intensity focused ultrasound (HIFU) ablation as a bridging therapy for patients with hepatocellular carcinoma (HCC) who had been wait‐listed for deceased donor liver transplantation (DDLT).

Long‐term effect of childhood liver transplantation on body cell mass

Looi Cheng Ee, Rebecca Joanne Hill, Kerrie Beale, Charlton Noble, Jonathan Fawcett, Geoffrey John Cleghorn – 18 April 2014 – Malnutrition is common in end‐stage liver disease, but a correction after transplantation is expected. Body cell mass (BCM) assessment using total body potassium (TBK) measurements is considered the gold standard for assessing nutritional status. The aim of this study was to examine the BCM and, therefore, nutritional status of long‐term survivors after childhood liver transplantation.

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