Outcomes of patients with cytomegalovirus viremia at the time of liver transplantation

Jackrapong Bruminhent, Raymund R. Razonable – 17 May 2014 – Cytomegalovirus (CMV) infection has been associated with poor outcomes after liver transplantation. Whether it is safe to perform transplantation for patients with active CMV viremia is not known. Here we report the outcomes of 6 patients with CMV viremia immediately before or at the time of liver transplantation.

HepG2 cells mount an effective antiviral interferon‐lambda based innate immune response to hepatitis C virus infection

Benjamin Israelow, Christopher M. Narbus, Marion Sourisseau, Matthew J. Evans – 16 May 2014 – Hepatitis C virus (HCV) exposure leads to persistent life‐long infections characterized by chronic inflammation often developing into cirrhosis and hepatocellular carcinoma. The mechanism by which HCV remains in the liver while inducing an inflammatory and antiviral response remains unclear.

MicroRNA‐331‐3p promotes proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine‐rich repeat protein phosphatase

Rui‐Min Chang, Hao Yang, Feng Fang, Jiang‐Feng Xu, Lian‐Yue Yang – 14 May 2014 – Hepatocellular carcinoma (HCC) is a highly invasive tumor with frequent intrahepatic or pulmonary metastasis, which is the main reason for high recurrence and poor survival of HCC after liver resection. However, the mechanisms for metastasis remain incompletely clear. Given that microRNAs (miRNAs) are implicated in HCC progression, we explored a potential role of miRNAs in metastasis by performing miRNA expression profiling in three subtypes of HCC with different metastatic potentials.

Hepatic DNA deposition drives drug‐induced liver injury and inflammation in mice

Pedro Elias Marques, André Gustavo Oliveira, Rafaela Vaz Pereira, Bruna Araújo David, Lindisley Ferreira Gomides, Adriana Machado Saraiva, Daniele Araújo Pires, Júlia Tosta Novaes, Daniel O. Patricio, Daniel Cisalpino, Zélia Menezes‐Garcia, W. Matthew Leevy, Sarah Ellen Chapman, GermánArturo Mahecha, Rafael Elias Marques, Rodrigo Guabiraba, Vicente Paulo Martins, Danielle Gloria Souza, Daniel Santos Mansur, Mauro Martins Teixeira, M.

Predictors of donor follow‐up after living donor liver transplantation

Robert S. Brown, Abigail R. Smith, Mary Amanda Dew, Brenda W. Gillespie, Peg Hill‐Callahan, Daniela P. Ladner – 13 May 2014 – Donor safety in living liver donation is of paramount importance; however, information on long‐term outcomes is limited by incomplete follow‐up. We sought to ascertain factors that predicted postdonation follow‐up in 456 living liver donors in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study. Completed donor follow‐up was defined as physical, phone, or laboratory contact at a given time point.

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