Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway

Takayoshi Shirasaki, Masao Honda, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shiomoto, Hikari Okada, Riuta Takabatake, Akihiro Tokumaru, Yoshio Sakai, Taro Yamashita, Stanley M. Lemon, Seishi Murakami, Shuichi Kaneko – 25 June 2014 – Malnutrition in the advanced fibrosis stage of chronic hepatitis C (CH‐C) impairs interferon (IFN) signaling by inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling. However, the effect of profibrotic signaling on IFN signaling is not known.

Laparoscopy‐assisted hepatectomy versus conventional (open) hepatectomy for living donors: When you know better, you do better

Kausar Makki, Vishal Kumar Chorasiya, Gaurav Sood, Piyush Kumar Srivastava, Puneet Dargan, Vivek Vij – 25 June 2014 – The conventional incision for donor hepatectomy is a right subcostal incision with a midline extension. With increased experience in both donor hepatectomy and laparoscopy, the conventional incision can be shortened to a significant extent. Laparoscopic mobilization of the liver coupled with a hand port allows the insertion of one hand inside the abdomen for control; this makes small‐incision donor hepatectomy a technically feasible alternative.

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