Giulia Castelli, Patrizia Burra, Anna Giacomin, Alessandro Vitale, Marco Senzolo, Umberto Cillo, Fabio Farinati – 9 May 2014 – Liver transplantation (LT) is an established treatment for hepatocellular carcinoma (HCC), and sorafenib (SFN) is a validated treatment for patients harboring advanced tumors. It is still not clear whether the combination of the 2 treatments, with SFN used in the neoadjuvant, adjuvant, or recurrence setting, is useful and cost‐effective.

Qiang Liu, Ahmed Nassar, Kevin Farias, Laura Buccini, William Baldwin, Martin Mangino, Ana Bennett, Colin O'Rourke, Toshiro Okamoto, Teresa Diago Uso, John Fung, Kareem Abu‐Elmagd, Charles Miller, Cristiano Quintini – 8 May 2014 – The effects of normothermic machine perfusion (NMP) on the postreperfusion hemodynamics and extrahepatic biliary duct histology of donation after cardiac death (DCD) livers after transplantation have not been addressed thoroughly and represent the objective of this study.

Maggie M. G. Ow, Paul Erasmus, Gary Minto, Richard Struthers, Moby Joseph, Aileen Smith, Usama M. Warshow, Matthew E. Cramp, Tim J. S. Cross – 8 May 2014 – Liver transplantation (LT) is a lifesaving treatment. Because of the shortage of donor organs, some patients will not survive long enough to receive a transplant. The identification of LT candidates at increased risk of short‐term mortality without transplantation may affect listing decisions.

Elisa J. Gordon, Michael G. Ison – 8 May 2014

Andrew H. Talal, Rositsa B. Dimova, Eileen Z. Zhang, Min Jiang, Marina S. Penney, James C. Sullivan, Martyn C. Botfield, Ananthsrinivas Chakilam, Rishikesh Sawant, Christine M. Cervini, Marija Zeremski, Ira M. Jacobson, Ann D. Kwong – 8 May 2014 – Understanding hepatitis C virus (HCV) replication has been limited by access to serial samples of liver, the primary site of viral replication. Our understanding of how HCV replicates and develops drug‐resistant variants in the liver is limited.

Jin‐Zhong Dong, Li‐Ping Wang, Sai‐Nan Zhang, Zhuo‐Lin Zou, Ming‐Qin Lu – 6 May 2014

Bilal Hameed, Neil Mehta, Gonzalo Sapisochin, John P. Roberts, Francis Y. Yao – 6 May 2014 – Serum alpha‐fetoprotein (AFP) has been increasingly recognized as a marker for a poor prognosis after liver transplantation (LT) for hepatocellular carcinoma (HCC). Many published reports, however, have included a large proportion of patients with HCC beyond the Milan criteria, and the effects of incorporating AFP as an exclusion criterion for LT remain unclear.

Juliane Winkler, Alessandro Ori, Kerstin Holzer, Carsten Sticht, Daniel Dauch, Eva Maria Eiteneuer, Federico Pinna, Robert Geffers, Volker Ehemann, Amparo Andres‐Pons, Kai Breuhahn, Thomas Longerich, Justo Lorenzo Bermejo, Norbert Gretz, Lars Zender, Peter Schirmacher, Martin Beck, Stephan Singer – 6 May 2014 – Proteins of the karyopherin superfamily including importins and exportins represent an essential part of the nucleocytoplasmic transport machinery. However, the functional relevance and regulation of karyopherins in hepatocellular carcinoma (HCC) is poorly understood.

Michael D. Aleo, Yi Luo, Rachel Swiss, Paul D. Bonin, David M. Potter, Yvonne Will – 6 May 2014 – Drug‐induced liver injury (DILI) accounts for 20‐40% of all instances of clinical hepatic failure and is a common reason for withdrawal of an approved drug or discontinuation of a potentially new drug from clinical/nonclinical development. Numerous individual risk factors contribute to the susceptibility to human DILI and its severity that are either compound‐ and/or patient‐specific.

Nir I. Nativ, Gabriel Yarmush, Ashley So, Jeffery Barminko, Timothy J. Maguire, Rene Schloss, Francois Berthiaume, Martin L. Yarmush – 6 May 2014 – Macrosteatotic livers exhibit elevated intrahepatic triglyceride (TG) levels in the form of large lipid droplets (LDs), reduced adenosine triphosphate (ATP) levels, and elevated reactive oxygen species (ROS) levels, and this contributes to their elevated sensitivity to ischemia/reperfusion injury during transplantation. Reducing macrosteatosis in living donors through dieting has been shown to improve transplant outcomes.