Generation of functional cholangiocyte‐like cells from human pluripotent stem cells and HepaRG cells

Noushin Dianat, Hélène Dubois‐Pot‐Schneider, Clara Steichen, Christophe Desterke, Philippe Leclerc, Aurélien Raveux, Laurent Combettes, Anne Weber, Anne Corlu, Anne Dubart‐Kupperschmitt – 9 April 2014 – Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development.

Generation of functional cholangiocyte‐like cells from human pluripotent stem cells and HepaRG cells

Noushin Dianat, Hélène Dubois‐Pot‐Schneider, Clara Steichen, Christophe Desterke, Philippe Leclerc, Aurélien Raveux, Laurent Combettes, Anne Weber, Anne Corlu, Anne Dubart‐Kupperschmitt – 9 April 2014 – Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development.

Index‐based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study

Wen‐Qing Li, Yikyung Park, Katherine A. McGlynn, Albert R. Hollenbeck, Philip R. Taylor, Alisa M. Goldstein, Neal D. Freedman – 9 April 2014 – The role of diet in hepatocellular carcinoma (HCC) and its typical precursor, chronic liver disease (CLD), is poorly understood. Following dietary recommendations has been shown to reduce risk of many cancers, but whether such diets are associated with HCC and CLD is unknown.

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism

Nicola Oehler, Tassilo Volz, Oliver D. Bhadra, Janine Kah, Lena Allweiss, Katja Giersch, Jeanette Bierwolf, Kristoffer Riecken, Jörg M. Pollok, Ansgar W. Lohse, Boris Fehse, Joerg Petersen, Stephan Urban, Marc Lütgehetmann, Joerg Heeren, Maura Dandri – 8 April 2014 – Chronic hepatitis B virus (HBV) infection has been associated with alterations in lipid metabolism. Moreover, the Na+‐taurocholate cotransporting polypeptide (NTCP), responsible for bile acid (BA) uptake into hepatocytes, was identified as the functional cellular receptor mediating HBV entry.

Patient‐reported outcomes in chronic hepatitis C patients with cirrhosis treated with sofosbuvir‐containing regimens

Zobair M. Younossi, Maria Stepanova, Fatema Nader, Ira M. Jacobson, Ed Gane, David Nelson, Eric Lawitz, Sharon L. Hunt – 8 April 2014 – Whether the presence of cirrhosis influences patient‐reported outcomes (PROs), including health‐related quality of life, during treatment with newly available anti‐HCV (hepatitis C virus) regimens is unclear. Our aim was to assess the association of cirrhosis with PROs in patients treated with sofosbuvir (SOF)‐containing regimens.

Caveolin‐1 is essential for protecting against binge drinking‐induced liver damage through inhibiting reactive nitrogen species

Lei Gao, Yingchun Zhou, Weichao Zhong, Xiaohua Zhao, Chun Chen, Xingmiao Chen, Yong Gu, Jianping Chen, Zhiping Lv, Jiangang Shen – 8 April 2014 – Caveolin‐1 (Cav‐1) is known to participate in many diseases, but its roles in alcoholic liver injury remain unknown. In the present study, we aimed to explore the roles of Cav‐1 in protecting hepatocytes from ethanol‐mediated nitrosative injury.

Perioperative complications in liver transplantation using donation after cardiac death grafts: A propensity‐matched study

Xiongxiong Pan, Worapot Apinyachon, Wei Xia, Johnny C. Hong, Ronald W. Busuttil, Randolph H. Steadman, Victor W. Xia – 8 April 2014 – Donation after cardiac death (DCD) is an important source for expanding the donor pool for liver transplantation (LT). Although the long‐term outcomes of LT using DCD grafts have been extensively studied, perioperative complications related to DCD grafts are rarely reported. The aim of this study was to determine whether DCD grafts were associated with a higher incidence of postreperfusion complications and worse outcomes in adult LT patients.

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