Emerging roles of Notch signaling in liver disease

Fabian Geisler, Mario Strazzabosco – 16 June 2014 – This review critically discusses the most recent advances in the role of Notch signaling in liver development, homeostasis, and disease. It is now clear that the significance of Notch in determining mammalian cell fates and functions extends beyond development, and Notch is a major regular of organ homeostasis. Moreover, Notch signaling is reactivated upon injury and regulates the complex interactions between the distinct liver cell types involved in the repair process.

Emerging roles of Notch signaling in liver disease

Fabian Geisler, Mario Strazzabosco – 16 June 2014 – This review critically discusses the most recent advances in the role of Notch signaling in liver development, homeostasis, and disease. It is now clear that the significance of Notch in determining mammalian cell fates and functions extends beyond development, and Notch is a major regular of organ homeostasis. Moreover, Notch signaling is reactivated upon injury and regulates the complex interactions between the distinct liver cell types involved in the repair process.

Timed regulation of P‐element‐induced wimpy testis–interacting RNA expression during rat liver regeneration

Francesca Rizzo, Adnan Hashim, Giovanna Marchese, Maria Ravo, Roberta Tarallo, Giovanni Nassa, Giorgio Giurato, Antonio Rinaldi, Angela Cordella, Marcello Persico, Pia Sulas, Andrea Perra, Giovanna M. Ledda‐Columbano, Amedeo Columbano, Alessandro Weisz – 16 June 2014 – Small noncoding RNAs comprise a growing family of molecules that regulate key cellular processes, including messenger RNA (mRNA) degradation, translational repression, and transcriptional gene silencing.

Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans

Nimzing G. Ladep, Anthony C. Dona, Matthew R. Lewis, Mary M.E. Crossey, Maud Lemoine, Edith Okeke, Yusuke Shimakawa, Mary Duguru, Harr F. Njai, Haddy K.S. Fye, Makie Taal, John Chetwood, Ben Kasstan, Shahid A. Khan, Deborah A. Garside, Anisha Wijeyesekera, Andrew V. Thillainayagam, Edmund Banwat, Mark R. Thursz, Jeremy K. Nicholson, Ramou Njie, Elaine Holmes, Simon D. Taylor‐Robinson – 13 June 2014 – There is no clinically applicable biomarker for surveillance of hepatocellular carcinoma (HCC), because the sensitivity of serum alpha‐fetoprotein (AFP) is too low for this purpose.

Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans

Nimzing G. Ladep, Anthony C. Dona, Matthew R. Lewis, Mary M.E. Crossey, Maud Lemoine, Edith Okeke, Yusuke Shimakawa, Mary Duguru, Harr F. Njai, Haddy K.S. Fye, Makie Taal, John Chetwood, Ben Kasstan, Shahid A. Khan, Deborah A. Garside, Anisha Wijeyesekera, Andrew V. Thillainayagam, Edmund Banwat, Mark R. Thursz, Jeremy K. Nicholson, Ramou Njie, Elaine Holmes, Simon D. Taylor‐Robinson – 13 June 2014 – There is no clinically applicable biomarker for surveillance of hepatocellular carcinoma (HCC), because the sensitivity of serum alpha‐fetoprotein (AFP) is too low for this purpose.

Medication level variability index predicts rejection, possibly due to nonadherence, in adult liver transplant recipients

Supelana Christina, Rachel A. Annunziato, Thomas D. Schiano, Ravinder Anand, Swapna Vaidya, Kelley Chuang, Yelena Zack, Sander Florman, Benjamin L. Shneider, Eyal Shemesh – 13 June 2014 – Nonadherence to immunosuppressants may play a role in late rejection in liver transplant recipients. In children, emerging data suggest that adherence can be measured through the computation of the standard deviation (SD) of consecutive blood levels of tacrolimus, which results in a number that reflects the degree of variability between individual measures: the medication level variability index (MLVI).

Subscribe to