Manlio Vinciguerra – 13 June 2014

Mitchell R. McGill, Vincent S. Staggs, Matthew R. Sharpe, William M. Lee, Hartmut Jaeschke, Acute Liver Failure Study Group – 13 June 2014 – Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Numerous studies have shown that APAP hepatotoxicity in mice involves mitochondrial dysfunction, and recent data suggest that this is also the case in humans.

Junpei Soeda, Angelina Mouralidarane, Shuvra Ray, Marco Novelli, Steven Thomas, Tania Roskams, Anna Mae Diehl, Jude A. Oben – 13 June 2014 – Acetaminophen (APAP)‐induced acute liver injury (AILI) is a major health problem. Accumulating evidence suggests that the sympathetic nervous system (SNS) regulates neuronal and hematopoietic progenitors. SNS signaling affects hepatic progenitor/oval cells (HPCs) and β‐adrenoceptor agonism will expand HPCs to reduce AILI.

Marco Marzioni, Laura Agostinelli, Cinzia Candelaresi, Stefania Saccomanno, Samuele Minicis, Luca Maroni, Eleonora Mingarelli, Chiara Rychlicki, Luciano Trozzi, Jesus M. Banales, Antonio Benedetti, Gianluca Svegliati Baroni – 13 June 2014

Yi‐Wen Huang, Sien‐Sing Yang, Szu‐Chieh Fu, Ting‐Chuan Wang, Cheng‐Kai Hsu, Ding‐Shinn Chen, Jui‐Ting Hu, Jia‐Horng Kao – 11 June 2014 – The effect of diabetes on cirrhosis, its decompensation, and their time relationship in chronic hepatitis C (CHC) patients remains unclear. We conducted a nation‐wide cohort study by using the Taiwanese National Health Insurance Research Database, which is comprised of data from >99% of the entire population. Among having randomly sampled 1 million enrollees, 6,251 adult CHC patients were identified from 1997 to 2009.

Fen Qiang Li, Gi‐Young Ko, Kyu‐Bo Sung, Dong‐Il Gwon, Heung Kyu Ko, Jong Woo Kim, Eunsil Yu – 10 June 2014 – The purpose of this study was to evaluate the efficacy and safety of transfemoral liver biopsy with a Quick‐Core biopsy needle in select living donor liver transplantation (LDLT) recipients. Eight LDLT recipients underwent 9 transfemoral liver biopsy sessions. Six patients had undergone modified right lobe (mRL) LDLT, and 2 patients had undergone dual–left lobe LDLT.

Eriks Smagris, Soumik BasuRay, John Li, Yongcheng Huang, Ka‐man V. Lai, Jesper Gromada, Jonathan C. Cohen, Helen H. Hobbs – 10 June 2014 – A sequence polymorphism (rs738409, I148M) in patatin‐like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild‐type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.

Eriks Smagris, Soumik BasuRay, John Li, Yongcheng Huang, Ka‐man V. Lai, Jesper Gromada, Jonathan C. Cohen, Helen H. Hobbs – 10 June 2014 – A sequence polymorphism (rs738409, I148M) in patatin‐like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild‐type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.

Jacinta A. Holmes, Gail V. Matthews, Alexander J. Thompson, on behalf of the CHARIOT Study Group – 10 June 2014

Georg Auzinger, Christopher Willars, Robert Loveridge, Thomas Best, Andre Vercueil, Andreas Prachalias, Michael A. Heneghan, Julia Wendon – 10 June 2014