Therapeutic strategy for anastomotic biliary strictures after pediatric liver transplantation: Two radically different approaches
Tom Darius, Raymond Reding – 18 June 2014
Timed regulation of P‐element‐induced wimpy testis–interacting RNA expression during rat liver regeneration
Francesca Rizzo, Adnan Hashim, Giovanna Marchese, Maria Ravo, Roberta Tarallo, Giovanni Nassa, Giorgio Giurato, Antonio Rinaldi, Angela Cordella, Marcello Persico, Pia Sulas, Andrea Perra, Giovanna M. Ledda‐Columbano, Amedeo Columbano, Alessandro Weisz – 16 June 2014 – Small noncoding RNAs comprise a growing family of molecules that regulate key cellular processes, including messenger RNA (mRNA) degradation, translational repression, and transcriptional gene silencing.
Emerging roles of Notch signaling in liver disease
Fabian Geisler, Mario Strazzabosco – 16 June 2014 – This review critically discusses the most recent advances in the role of Notch signaling in liver development, homeostasis, and disease. It is now clear that the significance of Notch in determining mammalian cell fates and functions extends beyond development, and Notch is a major regular of organ homeostasis. Moreover, Notch signaling is reactivated upon injury and regulates the complex interactions between the distinct liver cell types involved in the repair process.
Emerging roles of Notch signaling in liver disease
Fabian Geisler, Mario Strazzabosco – 16 June 2014 – This review critically discusses the most recent advances in the role of Notch signaling in liver development, homeostasis, and disease. It is now clear that the significance of Notch in determining mammalian cell fates and functions extends beyond development, and Notch is a major regular of organ homeostasis. Moreover, Notch signaling is reactivated upon injury and regulates the complex interactions between the distinct liver cell types involved in the repair process.
Activation of the developmental pathway neurogenin‐3/microRNA‐7a regulates cholangiocyte proliferation in response to injury
Marco Marzioni, Laura Agostinelli, Cinzia Candelaresi, Stefania Saccomanno, Samuele Minicis, Luca Maroni, Eleonora Mingarelli, Chiara Rychlicki, Luciano Trozzi, Jesus M. Banales, Antonio Benedetti, Gianluca Svegliati Baroni – 13 June 2014
The beta‐adrenoceptor agonist isoproterenol rescues acetaminophen‐injured livers through increasing progenitor numbers by Wnt in mice
Junpei Soeda, Angelina Mouralidarane, Shuvra Ray, Marco Novelli, Steven Thomas, Tania Roskams, Anna Mae Diehl, Jude A. Oben – 13 June 2014 – Acetaminophen (APAP)‐induced acute liver injury (AILI) is a major health problem. Accumulating evidence suggests that the sympathetic nervous system (SNS) regulates neuronal and hematopoietic progenitors. SNS signaling affects hepatic progenitor/oval cells (HPCs) and β‐adrenoceptor agonism will expand HPCs to reduce AILI.
Serum mitochondrial biomarkers and damage‐associated molecular patterns are higher in acetaminophen overdose patients with poor outcome
Mitchell R. McGill, Vincent S. Staggs, Matthew R. Sharpe, William M. Lee, Hartmut Jaeschke, Acute Liver Failure Study Group – 13 June 2014 – Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Numerous studies have shown that APAP hepatotoxicity in mice involves mitochondrial dysfunction, and recent data suggest that this is also the case in humans.
Protein intake, chronic liver diseases, and hepatocellular carcinoma
Manlio Vinciguerra – 13 June 2014
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Wen‐Qing Li, Yikyung Park, Katherine A. McGlynn, Albert R. Hollenbeck, Philip R. Taylor, Alisa M. Goldstein, Neal D. Freedman – 13 June 2014
Metabolic syndrome after pediatric liver transplantation
Silja Kosola, Hanna Lampela, Heikki Makisalo, Jouko Lohi, Johanna Arola, Hannu Jalanko, Mikko Pakarinen – 13 June 2014 – Half of adult liver transplantation (LT) recipients develop metabolic syndrome, but the prevalence after childhood LT remains unknown. We conducted a national cross‐sectional study of all living patients who had undergone LT between 1987 and 2007 at an age less than 18 years. We gathered information on blood pressure, body composition, serum lipids, glucose metabolism, and histological liver fat content.