Costs of telaprevir‐based triple therapy for hepatitis C: $189,000 per sustained virological response

Kian Bichoupan, Valerie Martel‐Laferriere, David Sachs, Michel Ng, Emily A. Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, Ponni V. Perumalswami, Thomas D. Schiano, Joseph A. Odin, Lawrence Liu, Alan J. Moskowitz, Douglas T. Dieterich, Andrea D.

Conjugated bilirubin triggers anemia by inducing erythrocyte death

Elisabeth Lang, Sergios Gatidis, Noemi F. Freise, Hans Bock, Ralf Kubitz, Christian Lauermann, Hans Martin Orth, Caroline Klindt, Maximilian Schuier, Verena Keitel, Maria Reich, Guilai Liu, Sebastian Schmidt, Haifeng C. Xu, Syed M. Qadri, Diran Herebian, Aleksandra A. Pandyra, Ertan Mayatepek, Erich Gulbins, Florian Lang, Dieter Häussinger, Karl S. Lang, Michael Föller, Philipp A.

Liver regeneration after living donor transplantation: Adult‐to‐adult living donor liver transplantation cohort study

Kim M. Olthoff, Jean C. Emond, Tempie H. Shearon, Greg Everson, Talia B. Baker, Robert A. Fisher, Chris E. Freise, Brenda W. Gillespie, James E. Everhart – 28 July 2014 – Adult‐to‐adult living donors and recipients were studied to characterize patterns of liver growth and identify associated factors in a multicenter study. Three hundred and fifty donors and 353 recipients in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study (A2ALL) receiving transplants between March 2003 and February 2010 were included.

Astrocyte elevated gene‐1 and c‐Myc cooperate to promote hepatocarcinogenesis in mice

Jyoti Srivastava, Ayesha Siddiq, Rachel Gredler, Xue‐Ning Shen, Devaraja Rajasekaran, Chadia L. Robertson, Mark A. Subler, Jolene J. Windle, Catherine I. Dumur, Nitai D. Mukhopadhyay, Dawn Garcia, Zhao Lai, Yidong Chen, Uthra Balaji, Paul B. Fisher, Devanand Sarkar – 28 July 2014 – Astrocyte elevated gene‐1 (AEG‐1) and c‐Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG‐1 is transcriptionally regulated by c‐Myc, and AEG‐1 itself induces c‐Myc by activating the Wnt/β‐catenin–signaling pathway.

Global distribution and prevalence of hepatitis C virus genotypes

Jane P. Messina, Isla Humphreys, Abraham Flaxman, Anthony Brown, Graham S. Cooke, Oliver G. Pybus, Eleanor Barnes – 28 July 2014 – Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends.

Conjugated bilirubin triggers anemia by inducing erythrocyte death

Elisabeth Lang, Sergios Gatidis, Noemi F. Freise, Hans Bock, Ralf Kubitz, Christian Lauermann, Hans Martin Orth, Caroline Klindt, Maximilian Schuier, Verena Keitel, Maria Reich, Guilai Liu, Sebastian Schmidt, Haifeng C. Xu, Syed M. Qadri, Diran Herebian, Aleksandra A. Pandyra, Ertan Mayatepek, Erich Gulbins, Florian Lang, Dieter Häussinger, Karl S. Lang, Michael Föller, Philipp A.

Hepatic inflammation and fibrosis: Functional links and key pathways

Ekihiro Seki, Robert F. Schwabe – 26 July 2014 – Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade, numerous studies have contributed to improved understanding of the links between hepatic inflammation and fibrosis.

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