Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma

Ze‐yang Ding, Guan‐nan Jin, Wei Wang, Wei‐xun Chen, Yan‐hui Wu, Xi Ai, Lin Chen, Wan‐guang Zhang, Hui‐fang Liang, Arian Laurence, Ming‐zhi Zhang, Pran K. Datta, Bixiang Zhang, Xiao‐ping Chen – 20 June 2014 – Transcriptional intermediary factor 1 gamma (TIF1γ) may play either a potential tumor‐suppressor or ‐promoter role in cancer. Here we report on a critical role of TIF1γ in the progression of hepatocellular carcinoma (HCC). Reduced expression of TIF1γ was detected in HCC, especially in advanced HCC tissues, compared to adjacent noncancerous tissues.

Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor–null mice by intestinal‐specific farnesoid X receptor reactivation

Chiara Degirolamo, Salvatore Modica, Michele Vacca, Giuseppe Di Tullio, Annalisa Morgano, Andria D'Orazio, Kristina Kannisto, Paolo Parini, Antonio Moschetta – 20 June 2014 – Farnesoid X receptor (FXR) is the master regulator of bile acid (BA) homeostasis because it controls BA synthesis, influx, efflux, and detoxification in the gut/liver axis. Deregulation of BA homeostasis has been linked to hepatocellular carcinoma (HCC), and spontaneous hepatocarcinogenesis has been observed in FXR‐null mice.

Analysis of factors associated with portal vein thrombosis in pediatric living donor liver transplant recipients

Joao Seda Neto, Eduardo A. Fonseca, Flávia H. Feier, Renata Pugliese, Helry L. Candido, Marcel R. Benavides, Gilda Porta, Irene K. Miura, Vera B. Danesi, Teresa Guimaraes, Adriana Porta, Cristian Borges, Andre Godoy, Mario Kondo, Paulo Chapchap – 20 June 2014 – The technique of vascular reconstruction plays a major role in the outcome of living donor liver transplantation (LDLT). An increased use of vascular grafts (VGs) as replacements for sclerotic portal veins has become a standard technique for our group.

Standing the test of time: Outcomes of a decade of prioritizing patients with hepatocellular carcinoma, results of the UNOS natural geographic experiment

Karim J. Halazun, Rachel E. Patzer, Abbas A. Rana, Elizabeth C. Verna, Adam D. Griesemer, Ronald F. Parsons, Benjamin Samstein, James V. Guarrera, Tomoaki Kato, Robert S. Brown, Jean C. Emond – 20 June 2014

Emerging roles of Notch signaling in liver disease

Fabian Geisler, Mario Strazzabosco – 16 June 2014 – This review critically discusses the most recent advances in the role of Notch signaling in liver development, homeostasis, and disease. It is now clear that the significance of Notch in determining mammalian cell fates and functions extends beyond development, and Notch is a major regular of organ homeostasis. Moreover, Notch signaling is reactivated upon injury and regulates the complex interactions between the distinct liver cell types involved in the repair process.

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