Junpei Soeda, Angelina Mouralidarane, Shuvra Ray, Marco Novelli, Steven Thomas, Tania Roskams, Anna Mae Diehl, Jude A. Oben – 13 June 2014 – Acetaminophen (APAP)‐induced acute liver injury (AILI) is a major health problem. Accumulating evidence suggests that the sympathetic nervous system (SNS) regulates neuronal and hematopoietic progenitors. SNS signaling affects hepatic progenitor/oval cells (HPCs) and β‐adrenoceptor agonism will expand HPCs to reduce AILI.

Mitchell R. McGill, Vincent S. Staggs, Matthew R. Sharpe, William M. Lee, Hartmut Jaeschke, Acute Liver Failure Study Group – 13 June 2014 – Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Numerous studies have shown that APAP hepatotoxicity in mice involves mitochondrial dysfunction, and recent data suggest that this is also the case in humans.

Manlio Vinciguerra – 13 June 2014

Wen‐Qing Li, Yikyung Park, Katherine A. McGlynn, Albert R. Hollenbeck, Philip R. Taylor, Alisa M. Goldstein, Neal D. Freedman – 13 June 2014

Silja Kosola, Hanna Lampela, Heikki Makisalo, Jouko Lohi, Johanna Arola, Hannu Jalanko, Mikko Pakarinen – 13 June 2014 – Half of adult liver transplantation (LT) recipients develop metabolic syndrome, but the prevalence after childhood LT remains unknown. We conducted a national cross‐sectional study of all living patients who had undergone LT between 1987 and 2007 at an age less than 18 years. We gathered information on blood pressure, body composition, serum lipids, glucose metabolism, and histological liver fat content.

Inka Wahl, Andreas Feige, Bernd Löwe, Christina Weiler‐Normann, Matthias Rose, Ansgar W. Lohse, Christoph Schramm – 13 June 2014

Supelana Christina, Rachel A. Annunziato, Thomas D. Schiano, Ravinder Anand, Swapna Vaidya, Kelley Chuang, Yelena Zack, Sander Florman, Benjamin L. Shneider, Eyal Shemesh – 13 June 2014 – Nonadherence to immunosuppressants may play a role in late rejection in liver transplant recipients. In children, emerging data suggest that adherence can be measured through the computation of the standard deviation (SD) of consecutive blood levels of tacrolimus, which results in a number that reflects the degree of variability between individual measures: the medication level variability index (MLVI).

Nimzing G. Ladep, Anthony C. Dona, Matthew R. Lewis, Mary M.E. Crossey, Maud Lemoine, Edith Okeke, Yusuke Shimakawa, Mary Duguru, Harr F. Njai, Haddy K.S. Fye, Makie Taal, John Chetwood, Ben Kasstan, Shahid A. Khan, Deborah A. Garside, Anisha Wijeyesekera, Andrew V. Thillainayagam, Edmund Banwat, Mark R. Thursz, Jeremy K. Nicholson, Ramou Njie, Elaine Holmes, Simon D. Taylor‐Robinson – 13 June 2014 – There is no clinically applicable biomarker for surveillance of hepatocellular carcinoma (HCC), because the sensitivity of serum alpha‐fetoprotein (AFP) is too low for this purpose.

Nimzing G. Ladep, Anthony C. Dona, Matthew R. Lewis, Mary M.E. Crossey, Maud Lemoine, Edith Okeke, Yusuke Shimakawa, Mary Duguru, Harr F. Njai, Haddy K.S. Fye, Makie Taal, John Chetwood, Ben Kasstan, Shahid A. Khan, Deborah A. Garside, Anisha Wijeyesekera, Andrew V. Thillainayagam, Edmund Banwat, Mark R. Thursz, Jeremy K. Nicholson, Ramou Njie, Elaine Holmes, Simon D. Taylor‐Robinson – 13 June 2014 – There is no clinically applicable biomarker for surveillance of hepatocellular carcinoma (HCC), because the sensitivity of serum alpha‐fetoprotein (AFP) is too low for this purpose.

Yi‐Wen Huang, Sien‐Sing Yang, Szu‐Chieh Fu, Ting‐Chuan Wang, Cheng‐Kai Hsu, Ding‐Shinn Chen, Jui‐Ting Hu, Jia‐Horng Kao – 11 June 2014 – The effect of diabetes on cirrhosis, its decompensation, and their time relationship in chronic hepatitis C (CHC) patients remains unclear. We conducted a nation‐wide cohort study by using the Taiwanese National Health Insurance Research Database, which is comprised of data from >99% of the entire population. Among having randomly sampled 1 million enrollees, 6,251 adult CHC patients were identified from 1997 to 2009.