Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype
Frédéric M. Vaz, Coen C. Paulusma, Hidde Huidekoper, Minke de Ru, Cynthia Lim, Janet Koster, Kam Ho‐Mok, Albert H. Bootsma, Albert K. Groen, Frank G. Schaap, Ronald P. J. Oude Elferink, Hans R. Waterham, Ronald J.A. Wanders – 28 May 2014 – The enterohepatic circulation of bile salts is an important physiological route to recycle bile salts and ensure intestinal absorption of dietary lipids. The Na+‐taurocholate cotransporting polypeptide SLC10A1 (NTCP) plays a key role in this process as the major transporter of conjugated bile salts from the plasma compartment into the hepatocyte.