Impact of anticoagulation on upper‐gastrointestinal bleeding in cirrhosis. A retrospective multicenter study

Federica Cerini, Javier Martínez Gonzalez, Ferran Torres, Ángela Puente, Meritxell Casas, Carmen Vinaixa, Marina Berenguer, Alba Ardevol, Salvador Augustin, Elba Llop, Maria Senosiaín, Càndid Villanueva, Joaquin de la Peña, Rafael Bañares, Joan Genescá, Júlia Sopeña, Agustín Albillos, Jaume Bosch, Virginia Hernández‐Gea, Juan Carlos Garcia‐Pagán – 12 March 2015 – Recent studies have shown that liver cirrhosis (LC) behaves as an acquired hypercoagulable state with increased thrombotic risk. This is why anticoagulation therapy (AT) is now frequently used in these patients.

Higher Mortality in registrants with sudden model for end‐stage liver disease increase: Disadvantaged by the current allocation policy

Allan B. Massie, Xun Luo, Jennifer L. Alejo, Anna K. Poon, Andrew M. Cameron, Dorry L. Segev – 12 March 2015 – Liver allocation is based on current Model for End‐Stage Liver Disease (MELD) scores, with priority in the case of a tie being given to those waiting the longest with a given MELD score. We hypothesized that this priority might not reflect risk: registrants whose MELD score has recently increased receive lower priority but might have higher wait‐list mortality. We studied wait‐list and posttransplant mortality in 69,643 adult registrants from 2002 to 2013.

Noninvasive assessment of macrovesicular liver steatosis in cadaveric donors based on computed tomography liver‐to‐spleen attenuation ratio

Julien Rogier, Stéphanie Roullet, François Cornélis, Matthieu Biais, Alice Quinart, Philippe Revel, Paulette Bioulac‐Sage, Brigitte Le Bail – 11 March 2015 – Fatty liver disease, including liver steatosis, is a major health problem worldwide. In liver transplantation, macrovesicular steatosis in donor livers is a major cause of graft failure and remains difficult to assess. On one hand, several imaging modalities can be used for the assessment of liver fat, but liver biopsy, which is still considered the gold standard, may be difficult to perform in this context.

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking

Solenne Marmier, Renaud Dentin, Martine Daujat‐Chavanieu, Hervé Guillou, Justine Bertrand‐Michel, Sabine Gerbal‐Chaloin, Jean Girard, Sophie Lotersztajn, Catherine Postic – 11 March 2015 – Carbohydrate responsive element binding protein (ChREBP) is central for de novo fatty acid synthesis under physiological conditions and in the context of nonalcoholic fatty liver disease. We explored its contribution to alcohol‐induced steatosis in a mouse model of binge drinking as acute ethanol (EtOH) intoxication has become an alarming health problem.

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis

Javier Michelena, José Altamirano, Juan G. Abraldes, Silvia Affò, Oriol Morales‐Ibanez, Pau Sancho‐Bru, Marlene Dominguez, Juan Carlos García‐Pagán, Javier Fernández, Vicente Arroyo, Pere Ginès, Alexandre Louvet, Philippe Mathurin, Wajahat Z. Mehal, Juan Caballería, Ramón Bataller – 11 March 2015 – Alcoholic hepatitis (AH) frequently progresses to multiple organ failure (MOF) and death. However, the driving factors are largely unknown. At admission, patients with AH often show criteria of systemic inflammatory response syndrome (SIRS) even in the absence of an infection.

Bone marrow‐derived progenitor cells in de novo liver regeneration in liver transplant

Sung‐Gyu Lee, Sung‐Hwan Moon, Hee‐Je Kim, Ji Yoon Lee, Soon‐Jung Park, Hyung‐Min Chung, Tae‐Yong Ha, Gi‐Won Song, Dong‐Hwan Jung, Hojong Park, Tae‐Won Kwon, Yong‐Pil Cho – 11 March 2015 – The study was designed (1) to examine the hypothesis that circulating progenitor cells play a role in the process of de novo regeneration in human liver transplants and that these cells arise from a cell population originating in, or associated with, the bone marrow and (2) to investigate whether the transplanted liver volume has an effect on the circulating recipient‐derived progenitor cells that generate

Serostatus following live attenuated vaccination administered before pediatric liver transplantation

Takanori Funaki, Kensuke Shoji, Ippei Miyata, Seisuke Sakamoto, Mureo Kasahara, Hironori Yoshii, Isao Miyairi, Akihiko Saitoh – 11 March 2015 – After liver transplantation (LT), live attenuated vaccines (LAVs) are generally contraindicated. LAVs are recommended before LT for patients ≥ 6 months of age. However, the evidence supporting this practice is limited. Patients were enrolled before and after LT. Clinical data for patients were obtained from medical records. Serum antibody titers were evaluated at the time of enrollment and prospectively.

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