Connective tissue growth factor and integrin αvβ6: A new pair of regulators critical for ductular reaction and biliary fibrosis in mice

Liya Pi, Paulette M. Robinson, Marda Jorgensen, Seh‐Hoon Oh, Alicia R. Brown, Paul H. Weinreb, Thu Le Trinh, Protopapadakis Yianni, Chen Liu, Andrew Leask, Shelia M. Violette, Edward W. Scott, Gregory S. Schultz, Bryon E. Petersen – 9 September 2014 – Connective tissue growth factor (CTGF) is a matricellular protein that mediates cell‐matrix interaction through various subtypes of integrin receptors.

Multicenter prospective validation of the Baveno IV and Baveno II/III criteria in cirrhosis patients with variceal bleeding

Dominique Thabut, Marika Rudler, Nina Dib, Nicolas Carbonell, Philippe Mathurin, Faouzi Saliba, Alain Mallet, Julien Massard, Brigitte Bernard‐Chabert, Frederic Oberti, Paul Cales, Jean‐Louis Golmard, Christophe Bureau, for the French Club for the Study of Portal Hypertension (CFEHTP) – 1 September 2014 – The criteria for defining failure to control bleeding in cirrhosis patients were introduced at the Baveno II/III meetings and were widely used as endpoints in clinical trials.

Subnormothermic ex vivo liver perfusion reduces endothelial cell and bile duct injury after donation after cardiac death pig liver transplantation

Jan M. Knaak, Vinzent N. Spetzler, Nicolas Goldaracena, Markus U. Boehnert, Fateh Bazerbachi, Kristine S. Louis, Oyedele A. Adeyi, Leonid Minkovich, Paul M. Yip, Shaf Keshavjee, Gary A. Levy, David R. Grant, Nazia Selzner, Markus Selzner – 1 September 2014 – An ischemic‐type biliary stricture (ITBS) is a common feature after liver transplantation using donation after cardiac death (DCD) grafts.

Renal replacement therapy in infants and children with hepatorenal syndrome awaiting liver transplantation: A case‐control study

C. Elizabeth Parsons, Raoul Nelson, Linda S. Book, M. Kyle Jensen – 1 September 2014 – Limited data on short‐ and long‐term outcomes of renal replacement therapy (RRT) in pediatric liver transplantation (LT) patients exist. We evaluated risk factors for RRT in pediatric LT recipients with hepatorenal syndrome (HRS) and described the outcomes. We performed a single‐center, case‐control study of LT recipients who required RRT for HRS from 1999 to 2011. Three controls who did not receive RRT were matched with each case on the basis of age, diagnosis, and LT date.

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

Chao Wang, Yuanlin Zhao, Xing Gao, Le Li, Yuan Yuan, Fang Liu, Lijun Zhang, Jie Wu, Peizhen Hu, Xiumin Zhang, Yu Gu, Yuqiao Xu, Zhe Wang, Zengshan Li, Huizhong Zhang, Jing Ye – 1 September 2014 – Abnormal metabolism of nonesterified fatty acids (NEFAs) and their derivatives has been reported to be the main cause of intracellular lipotoxic injury. Normally, NEFAs are stored in lipid droplets (LDs) in the form of triglyceride (TG), which could reduce the lipotoxicity of cytosolic NEFAs.

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