Yishai Avior, Gahl Levy, Michal Zimerman, Daniel Kitsberg, Robert Schwartz, Ronen Sadeh, Arieh Moussaieff, Merav Cohen, Joseph Itskovitz‐Eldor, Yaakov Nahmias – 22 March 2015 – The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes. However, the scarcity and variability of primary hepatocytes currently limits their utility.

Yishai Avior, Gahl Levy, Michal Zimerman, Daniel Kitsberg, Robert Schwartz, Ronen Sadeh, Arieh Moussaieff, Merav Cohen, Joseph Itskovitz‐Eldor, Yaakov Nahmias – 22 March 2015 – The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes. However, the scarcity and variability of primary hepatocytes currently limits their utility.

Rikita I. Hatia, Zoya Dimitrova, Pavel Skums, Elrond Yi‐Lang Teo, Chong‐Gee Teo – 22 March 2015 – The extent of provider‐to‐patient hepatitis C virus (HCV) transmission from diversion, self‐injection, and substitution (“tampering”) of anesthetic opioids is unknown. To quantify the contribution of opioid tampering to nosocomial HCV outbreaks, data from health care–related HCV outbreaks occurring in developed countries from 1990 to 2012 were collated, grouped, and compared. Tampering was associated with 17% (8 of 46) of outbreaks, but 53% (438 of 833) of cases.

Thomas Vanwolleghem, Jun Hou, Gertine van Oord, Arno C. Andeweg, A.D.M.E. Osterhaus, Suzan D. Pas, Harry L.A. Janssen, Andre Boonstra – 22 March 2015 – To identify immunological mechanisms that govern distinct clinical phases of a chronic hepatitis B virus (HBV) infection—immune tolerant (IT), immune active (IA), inactive carrier (IC), and hepatitis B e antigen (HBeAg)‐negative (ENEG) hepatitis phases—we performed a systems biology study.

Ângelo Zambam de Mattos, Angelo Alves de Mattos – 22 March 2015

Su‐Yeon Lee, In‐Kyung Hong, Bo‐Rahm Kim, Soon‐Mi Shim, Jae Sung Lee, Hui‐Young Lee, Cheol Soo Choi, Bo‐Kyung Kim, Tae‐Sik Park – 22 March 2015 – The endoplasmic reticulum (ER) is the principal organelle in the cell for protein folding and trafficking, lipid synthesis, and cellular calcium homeostasis. Perturbation of ER function results in activation of the unfolded protein response (UPR) and is implicated in abnormal lipid biosynthesis and development of insulin resistance.

Daniel Pineda‐Tenor, Mónica García‐Álvarez, María A. Jiménez‐Sousa, Amanda Fernández‐Rodríguez, Salvador Resino – 21 March 2015

Felix Heymann, Julia Peusquens, Isis Ludwig‐Portugall, Marlene Kohlhepp, Can Ergen, Patricia Niemietz, Christian Martin, Nico van Rooijen, Jordi C. Ochando, Gwendalyn J. Randolph, Tom Luedde, Florent Ginhoux, Christian Kurts, Christian Trautwein, Frank Tacke – 21 March 2015

Matthew T. Kitson, Christoph Sarrazin, Pierluigi Toniutto, Stuart K. Roberts – 21 March 2015

De‐Ke Jiang, Xiao‐Pin Ma, Hongjie Yu, Guangwen Cao, Dong‐Lin Ding, Haitao Chen, Hui‐Xing Huang, Yu‐Zhen Gao, Xiao‐Pan Wu, Xi‐Dai Long, Hongxing Zhang, Youjie Zhang, Yong Gao, Tao‐Yang Chen, Wei‐Hua Ren, Pengyin Zhang, Zhuqing Shi, Wei Jiang, Bo Wan, Hexige Saiyin, Jianhua Yin, Yuan‐Feng Zhou, Yun Zhai, Pei‐Xin Lu, Hongwei Zhang, Xiaoli Gu, Aihua Tan, Jin‐Bing Wang, Xian‐Bo Zuo, Liang‐Dan Sun, Jun O. Liu, Qing Yi, Zengnan Mo, Gangqiao Zhou, Ying Liu, Jielin Sun, Yin Yao Shugart, S.