Right lobe split liver transplantation versus whole liver transplantation in adult recipients: A systematic review and meta‐analysis

Ping Wan, Qigen Li, Jianjun Zhang, Qiang Xia – 2 April 2015 – Split liver transplantation (SLT) has proven to be an effective technique to reduce the mortality of children on the waiting list, but whether creating 2 split grafts from 1 standard‐criteria whole liver would compromise outcomes of adult recipients remains uncertain. We conducted this meta‐analysis to compare outcomes of right lobe SLT and whole liver transplantation (WLT) in adult patients. PubMed, Embase, and the Cochrane Library were searched for relevant articles published before December 2014.

Telbivudine in liver transplant recipients: Renal protection does not overcome the risk of polyneuropathy and myopathy

Ilker Turan, Suna Yapali, Fikret Bademkiran, Timur Kose, Soner Duman, Murat Sozbilen, Fulya Gunsar, Galip Ersoz, Ulus Salih Akarca, Omer Ozutemiz, Zeki Karasu – 2 April 2015 – The recently reported benefit of telbivudine for renal function has not been systematically studied in long‐term liver transplantation (LT) recipients who are at high risk for renal impairment. We aimed to examine whether switching lamivudine therapy to telbivudine could improve renal function in LT recipients who have impaired renal function.

Ledipasvir‐sofosbuvir plus ribavirin for patients with genotype 1 hepatitis C virus previously treated in clinical trials of sofosbuvir regimens

David Wyles, Paul Pockros, Giuseppe Morelli, Ziad Younes, Evguenia Svarovskaia, Jenny C. Yang, Phillip S. Pang, Yanni Zhu, John G. McHutchison, Steven Flamm, Eric Lawitz – 2 April 2015 – Patients who fail to achieve sustained virological response (SVR) after treatment with sofosbuvir (SOF) plus ribavirin (RBV) with or without pegylated interferon (Peg‐IFN) do not have established retreatment options.

Increased risk of portal vein thrombosis in patients with cirrhosis due to nonalcoholic steatohepatitis

Jonathan G. Stine, Neeral L. Shah, Curtis K. Argo, Shawn J. Pelletier, Stephen H. Caldwell, Patrick G. Northup – 2 April 2015 – Portal vein thrombosis (PVT) is a common complication of cirrhosis sometimes implicated in hepatic decompensation. There are no consistent epidemiologic data to suggest an increased risk of thrombotic complications in nonalcoholic steatohepatitis (NASH); however, research suggests an increased risk of thrombosis.

Impact of Kasai portoenterostomy on liver transplantation outcomes: A retrospective cohort study of 347 children with biliary atresia

Joao Seda Neto, Flávia H. Feier, Ana Luiza Bierrenbach, Cristiana M. Toscano, Eduardo A. Fonseca, Renata Pugliese, Helry L. Candido, Marcel R. Benavides, Gilda Porta, Paulo Chapchap – 2 April 2015 – Biliary atresia (BA) is the main diagnosis leading to liver transplantation (LT) in children. When diagnosed early in life, a Kasai portoenterostomy (Kasai‐PE) can prevent or postpone LT. Instances of previous operations can result in difficulties during the LT. We hypothesized that a previous Kasai‐PE could affect LT outcomes.

Pulmonary nodules in liver transplant candidates with hepatocellular carcinoma: Imaging characteristics and clinical outcomes

Christopher Lee, Lauren Ihde, Andrew Kim, Idoia Santos, Lea Matsuoka, Yong Cen, Melissa Wallman, Edward Grant – 2 April 2015 – No guidelines exist for the management of pulmonary nodules in patients with hepatocellular carcinoma (HCC) who are being evaluated for liver transplantation. The 172 patients with HCC who were listed for liver transplant at our institution received both pretransplant chest computed tomography (CT) and follow‐up CT.

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