Liver transplant patients have a risk of progression similar to that of sporadic patients with branch duct intraductal papillary mucinous neoplasms

Anne Marie Lennon, David Victor, Atif Zaheer, Mohammad Reza Ostovaneh, Jessica Jeh, Joanna K. Law, Neda Rezaee, Marco Dal Molin, Young Joon Ahn, Wenchuan Wu, Mouen A. Khashab, Mohit Girotra, Nita Ahuja, Martin A. Makary, Matthew J. Weiss, Kenzo Hirose, Michael Goggins, Ralph H. Hruban, Andrew Cameron, Christopher L. Wolfgang, Vikesh K. Singh, Ahmet Gurakar – 25 August 2014 – Intraductal papillary mucinous neoplasms (IPMNs) have malignant potential and can progress from low‐ to high‐grade dysplasia to invasive adenocarcinoma.

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N‐Ras proto‐oncogenes in mice

Chunmei Wang, Antonio Cigliano, Lijie Jiang, Xiaolei Li, Biao Fan, Maria G. Pilo, Yan Liu, Bing Gui, Marcella Sini, Jeffrey W. Smith, Frank Dombrowski, Diego F. Calvisi, Matthias Evert, Xin Chen – 22 August 2014 – Concomitant expression of activated forms of v‐akt murine thymoma viral oncogene homolog (AKT) and Ras in mouse liver (AKT/Ras) leads to rapid tumor development through strong activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway.

Myeloid‐specific disruption of recombination signal binding protein Jκ ameliorates hepatic fibrosis by attenuating inflammation through cylindromatosis in mice

Fei He, Feng‐Cheng Guo, Zhi Li, Heng‐Chao Yu, Peng‐Fei Ma, Jun‐Long Zhao, Lei Feng, Wei‐Na Li, Xiao‐Wei Liu, Hong‐Yan Qin, Ke‐Feng Dou, Hua Han – 22 August 2014 – Macrophages play multidimensional roles in hepatic fibrosis, but their control has not been fully understood. The Notch pathway mediated by recombination signal binding protein Jκ (RBP‐J), the transcription factor transactivated by signals from four mammalian Notch receptors, is implicated in macrophage activation and plasticity.

Reply

Tamer Abdelrahman, Joseph Hughes, Janice Main, John McLauchlan, Mark Thursz, Emma Thomson – 22 August 2014

Subscribe to