Early allograft dysfunction in liver transplantation with donation after cardiac death donors results in inferior survival

David D. Lee, Amandeep Singh, Justin M. Burns, Dana K. Perry, Justin H. Nguyen, C. Burcin Taner – 1 September 2014 – Donation after cardiac death (DCD) liver allografts have been associated with increased morbidity from primary nonfunction, biliary complications, early allograft failure, cost, and mortality. Early allograft dysfunction (EAD) after liver transplantation has been found to be associated with inferior patient and graft survival.

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

Chao Wang, Yuanlin Zhao, Xing Gao, Le Li, Yuan Yuan, Fang Liu, Lijun Zhang, Jie Wu, Peizhen Hu, Xiumin Zhang, Yu Gu, Yuqiao Xu, Zhe Wang, Zengshan Li, Huizhong Zhang, Jing Ye – 1 September 2014 – Abnormal metabolism of nonesterified fatty acids (NEFAs) and their derivatives has been reported to be the main cause of intracellular lipotoxic injury. Normally, NEFAs are stored in lipid droplets (LDs) in the form of triglyceride (TG), which could reduce the lipotoxicity of cytosolic NEFAs.

Renal replacement therapy in infants and children with hepatorenal syndrome awaiting liver transplantation: A case‐control study

C. Elizabeth Parsons, Raoul Nelson, Linda S. Book, M. Kyle Jensen – 1 September 2014 – Limited data on short‐ and long‐term outcomes of renal replacement therapy (RRT) in pediatric liver transplantation (LT) patients exist. We evaluated risk factors for RRT in pediatric LT recipients with hepatorenal syndrome (HRS) and described the outcomes. We performed a single‐center, case‐control study of LT recipients who required RRT for HRS from 1999 to 2011. Three controls who did not receive RRT were matched with each case on the basis of age, diagnosis, and LT date.

Subnormothermic ex vivo liver perfusion reduces endothelial cell and bile duct injury after donation after cardiac death pig liver transplantation

Jan M. Knaak, Vinzent N. Spetzler, Nicolas Goldaracena, Markus U. Boehnert, Fateh Bazerbachi, Kristine S. Louis, Oyedele A. Adeyi, Leonid Minkovich, Paul M. Yip, Shaf Keshavjee, Gary A. Levy, David R. Grant, Nazia Selzner, Markus Selzner – 1 September 2014 – An ischemic‐type biliary stricture (ITBS) is a common feature after liver transplantation using donation after cardiac death (DCD) grafts.

Multicenter prospective validation of the Baveno IV and Baveno II/III criteria in cirrhosis patients with variceal bleeding

Dominique Thabut, Marika Rudler, Nina Dib, Nicolas Carbonell, Philippe Mathurin, Faouzi Saliba, Alain Mallet, Julien Massard, Brigitte Bernard‐Chabert, Frederic Oberti, Paul Cales, Jean‐Louis Golmard, Christophe Bureau, for the French Club for the Study of Portal Hypertension (CFEHTP) – 1 September 2014 – The criteria for defining failure to control bleeding in cirrhosis patients were introduced at the Baveno II/III meetings and were widely used as endpoints in clinical trials.

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