Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection

Mariko Esumi, Mariko Ishibashi, Hiromi Yamaguchi, Satomi Nakajima, Yuhi Tai, Sachiko Kikuta, Masahiko Sugitani, Tadatoshi Takayama, Maino Tahara, Makoto Takeda, Takaji Wakita – 9 September 2014 – The human liver reacts to hepatitis C virus (HCV) with a balanced response consisting of host anti‐ and proviral activities. To explore these subtle host responses, we used oligonucleotide microarrays to investigate the differential gene expression between two groups of liver samples with high and low HCV loads (>100‐fold difference).

Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: The Chronic Hepatitis Cohort Study (CHeCS)

Joseph A. Boscarino, Mei Lu, Anne C. Moorman, Stuart C. Gordon, Loralee B. Rupp, Philip R. Spradling, Eyasu H. Teshale, Mark A. Schmidt, Vinutha Vijayadeva, Scott D. Holmberg, for the Chronic Hepatitis Cohort Study (CHeCS) Investigators – 9 September 2014 – Our objective was to assess the extent and risk factors for depression and poor physical health among patients with chronic hepatitis C virus (HCV) infection. We surveyed HCV‐infected patients seen at four large healthcare systems participating in the Chronic Hepatitis Cohort Study (CHeCS).

Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic hepatitis C virus, genotype 1–infected patients

Eric G. Meissner, Yu‐Jin Lee, Anu Osinusi, Zayani Sims, Jing Qin, Dan Sturdevant, John McHutchison, Mani Subramanian, Maureen Sampson, Susanna Naggie, Keyur Patel, Alan T. Remaley, Henry Masur, Shyam Kottilil – 9 September 2014 – Hepatitis C virus (HCV) modulates intrahepatic cholesterol biosynthetic pathways to promote viral replication. Chronic HCV infection is associated with altered metabolism, including dyslipidemia and insulin resistance (IR), which contributes to disease progression and influences response to therapy.

Early allograft dysfunction in liver transplantation with donation after cardiac death donors results in inferior survival

David D. Lee, Amandeep Singh, Justin M. Burns, Dana K. Perry, Justin H. Nguyen, C. Burcin Taner – 1 September 2014 – Donation after cardiac death (DCD) liver allografts have been associated with increased morbidity from primary nonfunction, biliary complications, early allograft failure, cost, and mortality. Early allograft dysfunction (EAD) after liver transplantation has been found to be associated with inferior patient and graft survival.

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