Hepatocytes from induced pluripotent stem cells: A giant leap forward for hepatology
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G. Ian Gallicano, Lopa Mishra – 23 December 2009
Long‐term outcomes of positive fluorescence in situ hybridization tests in primary sclerosing cholangitis
Sanjay Y. Bangarulingam, Einar Bjornsson, Felicity Enders, Emily G. Barr Fritcher, Gregory Gores, Kevin C. Halling, Keith D. Lindor – 23 December 2009 – Patients with primary sclerosing cholangitis (PSC) are at increased risk for developing cholangiocarcinoma (CCA). Fluorescence in situ hybridization (FISH) is a cytological test designed to enhance early CCA diagnosis. The long‐term outcome of PSC patients with a positive FISH test (polysomy, trisomy/tetrasomy) are unclear.
Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease
Lauren N. Bell, Janice L. Theodorakis, Raj Vuppalanchi, Romil Saxena, Kerry G. Bemis, Mu Wang, Naga Chalasani – 23 December 2009 – Nonalcoholic fatty liver disease (NAFLD), ranging from relatively benign simple steatosis to progressive nonalcoholic steatohepatitis (NASH) and fibrosis, is an increasingly common chronic liver disease. Liver biopsy is currently the only reliable tool for staging the subtypes of NAFLD; therefore, noninvasive serum biomarkers for evaluation of liver disease and fibrosis are urgently needed.
Alcoholic liver disease
Robert S. O'Shea, Srinivasan Dasarathy, Arthur J. McCullough, Practice Guideline Committee of the American Association for the Study of Liver Diseases and the Practice Parameters Committee of the American College of Gastroenterology – 23 December 2009
Long‐term efficacy of tenofovir monotherapy for hepatitis B virus‐monoinfected patients after failure of nucleoside/nucleotide analogues
Florian van Bömmel, Robert A. de Man, Heiner Wedemeyer, Katja Deterding, Jörg Petersen, Peter Buggisch, Andreas Erhardt, Dietrich Hüppe, Kerstin Stein, Jörg Trojan, Christoph Sarrazin, Wulf O. Böcher, Ulrich Spengler, Hermann E. Wasmuth, Jurrien G.P.
Interleukin‐17–producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B
Ji‐Yuan Zhang, Zheng Zhang, Fang Lin, Zheng‐Sheng Zou, Ruo‐Nan Xu, Lei Jin, Jun‐Liang Fu, Feng Shi, Ming Shi, Hui‐Fen Wang, Fu‐Sheng Wang – 23 December 2009 – Interleukin‐17 (IL‐17)‐producing CD4+ T cells (Th17)‐mediated immune response has been demonstrated to play a critical role in inflammation‐associated disease; however, its role in chronic hepatitis B virus (HBV) infection remains unknown.
Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells
Michelina Nascimbeni, Thomas Montange, Helen K. W. Law, Vincent Mallet, Bertrand Saunier, Yves Rivière, Stanislas Pol – 23 December 2009
Fluorescent in situ hybridization testing in primary sclerosing cholangitis: Useful testing or a random chance result?
William C. Chapman – 23 December 2009
N‐acetylcysteine on its way to a broader application in patients with acute liver failure
Alexander Koch, Christian Trautwein – 23 December 2009
Kupffer cell and interleukin‐12–dependent loss of natural killer T cells in hepatosteatosis
Michael Kremer, Emmanuel Thomas, Richard J. Milton, Ashley W. Perry, Nico van Rooijen, Michael D. Wheeler, Steven Zacks, Michael Fried, Richard A. Rippe, Ian N. Hines – 23 December 2009 – Hepatosteatosis is associated with increased expression of tumor necrosis factor alpha (TNF‐α) and interleukin (IL)‐12, major T helper (Th) 1 cytokines, and reduced hepatic natural killer T (NKT) cell numbers. The relationship between lipid accumulation, cytokine expression, and hepatic NKT cells is not known.