Pancreatic‐derived factor promotes lipogenesis in the mouse liver: Role of the Forkhead box 1 signaling pathway

Jing Li, Yujing Chi, Chunjiong Wang, Jing Wu, Hang Yang, Dongjuan Zhang, Yi Zhu, Nanping Wang, Jichun Yang, Youfei Guan – 15 March 2011 – Pancreatic‐derived factor (PANDER) is a pancreatic islet‐specific cytokine that cosecretes with insulin and is important for β cell function. Here, we show that PANDER is constitutively expressed in hepatocytes, and its expression is significantly increased in steatotic livers of diabetic insulin‐resistant db/db mice and mice fed a high‐fat diet.

A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis

Peggy Raynaud, Joshua Tate, Céline Callens, Sabine Cordi, Patrick Vandersmissen, Rodolphe Carpentier, Christine Sempoux, Olivier Devuyst, Christophe E. Pierreux, Pierre Courtoy, Karin Dahan, Katty Delbecque, Sébastien Lepreux, Marco Pontoglio, Lisa M. Guay‐Woodford, Frédéric P. Lemaigre – 9 March 2011 – Ductal plate malformations (DPMs) are developmental anomalies considered to result from lack of ductal plate remodeling during bile duct morphogenesis.

Liver receptor homolog‐1 is critical for adequate up‐regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration

Carolien Out, Jurre Hageman, Vincent W. Bloks, Han Gerrits, Maarten D. Sollewijn Gelpke, Trijnie Bos, Rick Havinga, Martin J. Smit, Folkert Kuipers, Albert K. Groen – 9 March 2011 – Liver receptor homolog‐1 (LRH‐1) is a nuclear receptor that controls a variety of metabolic pathways. In cultured cells, LRH‐1 induces the expression of CYP7A1 and CYP8B1, key enzymes in bile salt synthesis. However, hepatic Cyp7a1 mRNA levels were not reduced upon hepatocyte‐specific Lrh‐1 deletion in mice. The reason for this apparent paradox has remained elusive.

Antitumor effects of OSU‐2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma

Hany A. Omar, Chih‐Chien Chou, Lisa D. Berman‐Booty, Yihui Ma, Jui‐Hsiang Hung, Dasheng Wang, Takayuki Kogure, Tushar Patel, Luigi Terracciano, Natarajan Muthusamy, John C. Byrd, Samuel K. Kulp, Ching‐Shih Chen – 9 March 2011 – Accumulating evidence suggests the therapeutic potential of the immunosuppressive agent FTY720 (fingolimod) in hepatocellular carcinoma (HCC).

Novel roles of galectin‐1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth

María V. Espelt, Diego O. Croci, María L. Bacigalupo, Pablo Carabias, Malena Manzi, María T. Elola, Marina C. Muñoz, Fernando P. Dominici, Carlota Wolfenstein‐Todel, Gabriel A. Rabinovich, María F. Troncoso – 9 March 2011 – Galectin‐1 (Gal‐1), a widely expressed β‐galactoside–binding protein, exerts pleiotropic biological functions. Gal‐1 is up‐regulated in hepatocarcinoma cells, although its role in liver pathophysiology remains uncertain. We investigated the effects of Gal‐1 on HepG2 hepatocellular carcinoma (HCC) cell adhesion and polarization.

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up‐regulation of lipogenic genes in heparg cells

Sébastien Anthérieu, Alexandra Rogue, Bernard Fromenty, André Guillouzo, Marie‐Anne Robin – 9 March 2011 – Drug‐induced liver injury occurs in general after several weeks and is often unpredictable. It is characterized by a large spectrum of lesions that includes steatosis and phospholipidosis. Many drugs such as amiodarone and tetracycline have been reported to cause phospholipidosis and/or steatosis. In this study, acute and chronic hepatic effects of these two drugs were investigated using well‐differentiated human hepatoma HepaRG cells.

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