Correction
24 February 2009
Serum alanine aminotransferase level alone may not accurately represent necro‐inflammation in patients with acute hepatitis
Yeon Seok Seo, Soon Ho Um, Eun Suk Jung, Hyung Joon Yim, Chang Duck Kim, Ho Sang Ryu – 24 February 2009
Expanding transplant criteria for hepatocellular carcinoma: Small steps down a long road
William Sanchez – 24 February 2009
The quest for liver fibrosis biomarkers: Promises from the enhanced liver fibrosis panel and beyond
Yusuf Yilmaz, Engin Ulukaya, Enver Dolar – 24 February 2009
Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection
Nirupma TrehanPati, Robert Geffers, Sukriti, Syed Hissar, Peggy Riese, Tanja Toepfer, Jan Buer, Manoj Kumar, Carlos A. Guzman, Shiv Kumar Sarin – 24 February 2009 – CD4+ T and regulatory T cells (Tregs) seem to play a key role in persistence of hepatitis B virus (HBV) infection. However, the molecular events by which Tregs exert their modulatory activity are largely unknown.
Early gene expression profiles of patients with chronic hepatitis C treated with pegylated interferon‐alfa and ribavirin
Zobair M. Younossi, Ancha Baranova, Arian Afendy, Rochelle Collantes, Maria Stepanova, Ganiraju Manyam, Anita Bakshi, Christopher L. Sigua, Joanne P. Chan, Ayuko A. Iverson, Christopher D. Santini, Sheng‐Yung P. Chang – 24 February 2009 – Responsiveness to hepatitis C virus (HCV) therapy depends on viral and host factors. Our aim was to assess sustained virologic response (SVR)‐associated early gene expression in patients with HCV receiving pegylated interferon‐alpha2a (PEG‐IFN‐α2a) or PEG‐IFN‐α2b and ribavirin with the duration based on genotypes.
Apotopes and the biliary specificity of primary biliary cirrhosis
Ana Lleo, Carlo Selmi, Pietro Invernizzi, Mauro Podda, Ross L. Coppel, Ian R. Mackay, Gregory J. Gores, Aftab A. Ansari, Judy Van de Water, M. Eric Gershwin – 24 February 2009 – Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC‐E2). Notwithstanding the presence of mitochondria in virtually all nucleated cells, the destruction in PBC is limited to small intrahepatic bile ducts.
Efficient hepatocyte engraftment and long‐term transgene expression after reversible portal embolization in nonhuman primates
Ibrahim Dagher, Tuan Huy Nguyen, Marie‐Thérèse Groyer‐Picard, Panagiotis Lainas, Sylvie Mainot, Catherine Guettier, Danièle Pariente, Dominique Franco, Anne Weber – 24 February 2009 – The feasibility of ex vivo gene therapy as an alternative to liver transplantation for the treatment of liver metabolic diseases needs to be analyzed in large animal models. This approach requires appropriate gene transfer vectors and effective hepatocyte engraftment.
Liver biopsy
Don C. Rockey, Stephen H. Caldwell, Zachary D. Goodman, Rendon C. Nelson, Alastair D. Smith – 24 February 2009
The Marburg I variant (G534E) of the factor VII–activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet‐derived growth factor BB
Hermann E. Wasmuth, Carmen G. Tag, Eddie Van de Leur, Claus Hellerbrand, Tobias Mueller, Thomas Berg, Gero Puhl, Peter Neuhaus, Didier Samuel, Christian Trautwein, Sandip M. Kanse, Ralf Weiskirchen – 24 February 2009 – Genetic risk factors play an important role for the progression of liver fibrosis in chronic hepatitis C virus (HCV) infection, but functional data on specific alleles and their related proteins are limited.