Biliary reconstruction for infantile living donor liver transplantation: Roux‐en‐Y hepaticojejunostomy or duct‐to‐duct choledochocholedochostomy?

Yasumasa Shirouzu, Hideaki Okajima, Satsuki Ogata, Yuki Ohya, Yukika Tsukamoto, Hidekazu Yamamoto, Takayuki Takeichi, Lee Kwang‐Jong, Katsuhiro Asonuma, Yukihiro Inomata – 24 November 2008 – Hepaticojejunostomy is a standard biliary reconstruction method for infantile living donor liver transplantation (LDLT), but choledochocholedochostomy for infants is not generally accepted yet. Ten pediatric recipients weighing no more than 10 kg underwent duct‐to‐duct choledochocholedochostomy (DD) for biliary reconstruction for LDLT.

Report of the Paris consensus meeting on expanded criteria donors in liver transplantation

François Durand, John F. Renz, Barbara Alkofer, Patrizia Burra, Pierre‐Alain Clavien, Robert J. Porte, Richard B. Freeman, Jacques Belghiti – 24 November 2008 – Because of organ shortage and a constant imbalance between available organs and candidates for liver transplantation, expanded criteria donors are needed. Experience shows that there are wide variations in the definitions, selection criteria, and use of expanded criteria donors according to different geographic areas and different centers. Overall, selection criteria for donors have tended to be relaxed in recent years.

Liver regeneration in donors and adult recipients after living donor liver transplantation

Junko Haga, Motohide Shimazu, Go Wakabayashi, Minoru Tanabe, Shigeyuki Kawachi, Yasushi Fuchimoto, Ken Hoshino, Yasuhide Morikawa, Masaki Kitajima, Yuko Kitagawa – 24 November 2008 – In living donor liver transplantation, the safety of the donor operation is the highest priority. The introduction of the right lobe graft was late because of concerns about donor safety. We investigated donor liver regeneration by the types of resected segments as well as recipients to assess that appropriate regeneration was occurring.

Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway

Hannah R. Walden, John A. Kirby, Stephen J. Yeaman, Joe Gray, David E. Jones, Jeremy M. Palmer – 24 November 2008 – Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC‐E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto‐epitopes. A candidate mechanism for the initiation of tolerance breakdown in this disease is immune recognition of neo‐antigens formed by xenobiotic substitution of normal proteins.

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