Toll‐like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury
Justin D. Ellett, Zachary P. Evans, Carl Atkinson, Michael G. Schmidt, Rick G. Schnellmann, Kenneth D. Chavin – 28 August 2009 – Steatotic donors are routinely rejected for transplantation because of their increased rate of primary nonfunction. These grafts are more sensitive to ischemia/reperfusion (I/R) during transplantation. Removal of endotoxin before reperfusion improves liver performance post‐I/R. We hypothesize that the main modality of injury in steatotic livers is toll‐like receptor 4 (TLR4) signaling.