Intraoperative renal support during liver transplantation

Derek R. Townsend, Sean M. Bagshaw, Michael J. Jacka, David Bigam, Dominic Cave, R. T. Noel Gibney – 24 December 2008 – Acute kidney injury (AKI) is common in liver failure prior to orthotopic liver transplantation (OLT) and may complicate the intraoperative course. We describe the logistics of intraoperative continuous renal replacement therapy (CRRT) during OLT and the associated clinical outcomes.

Subnormothermic machine perfusion protects steatotic livers against preservation injury: A potential for donor pool increase?

Mariapia Vairetti, Andrea Ferrigno, Filippo Carlucci, Antonella Tabucchi, Vittoria Rizzo, Eleonora Boncompagni, Daniele Neri, Enrico Gringeri, Isabel Freitas, Umberto Cillo – 24 December 2008 – We tested whether rat liver preservation performed by machine perfusion (MP) at 20°C can enhance the functional integrity of steatotic livers versus simple cold storage. We also compared MP at 20°C with hypothermic MP at 8°C, and 4°C. Obese and lean male Zucker rats were used as liver donors. MP was performed for 6 hours with a glucose and N‐acetylcysteine–supplemented Krebs‐Henseleit solution.

Cirrhosis of mixed etiology (hepatitis C virus and alcohol): Posttransplantation outcome—Comparison with hepatitis C virus–related cirrhosis and alcoholic‐related cirrhosis

Victoria Aguilera, Marina Berenguer, Angel Rubín, Fernando San‐Juan, Jose‐Miguel Rayón, Martín Prieto, José Mir – 24 December 2008 – Hepatitis C virus (HCV)‐related liver disease is enhanced by alcohol consumption. Of HCV‐related liver transplantation (LT) recipients, 25% have a history of alcohol intake. The purpose of this research was to determine whether LT outcome differs between patients with cirrhosis of mixed etiology compared to HCV or alcohol alone.

Sildenafil therapy is associated with improved hemodynamics in liver transplantation candidates with pulmonary arterial hypertension

Michael S. Gough, R. James White – 24 December 2008 – Pulmonary arterial hypertension associated with portal hypertension occurs in about 5% of patients being evaluated for liver transplantation. Treatment is required to facilitate safe transplantation, and oral pulmonary vasodilators have yet to be prospectively evaluated for this disease. The objective of this study was to determine the hemodynamic outcome in a consecutive cohort of patients offered sildenafil as first‐line treatment for portopulmonary hypertension.

Impact of donor graft steatosis on overall outcome and viral recurrence after liver transplantation for hepatitis C virus cirrhosis

Javier Briceño, Ruben Ciria, María Pleguezuelo, Manuel de la Mata, Jordi Muntané, Álvaro Naranjo, Juan Sánchez‐Hidalgo, Trinidad Marchal, Sebastián Rufián, Pedro López‐Cillero – 24 December 2008 – The aim of this study was to determine the influence of donor graft steatosis on overall outcome, viral recurrence, and fibrosis progression in orthotopic liver transplantation (OLT) for hepatitis C virus (HCV) cirrhosis. One hundred twenty patients who underwent OLT for HCV cirrhosis between 1995 and 2005 were included in the study.

Hepatocyte transplantation in animal models

Anne Weber, Marie‐Thérèse Groyer‐Picard, Dominique Franco, Ibrahim Dagher – 24 December 2008 – More than 30 years after the first hepatocyte transplant to treat the Gunn rat, the animal model for Crigler‐Najjar syndrome, there are still a number of impediments to hepatocyte transplantation. Numerous animal models are still used in work aimed at improving hepatocyte engraftment and/or long‐term function.

Subscribe to