Insights into defibrotide as therapy for veno‐occlusive disease
Jennifer R. Gamble, Mathew A. Vadas – 28 January 2009
Significant correlation between spleen volume and thrombocytopenia in liver transplant patients: A concept for predicting persistent thrombocytopenia
Masahiro Ohira, Minoru Ishifuro, Kentaro Ide, Toshimitsu Irei, Hirotaka Tashiro, Toshiyuki Itamoto, Katsuhide Ito, Kazuaki Chayama, Toshimasa Asahara, Hideki Ohdan – 28 January 2009 – Interferon (IFN) therapy with or without ribavirin treatment is well established as a standard antiviral treatment for hepatitis C virus (HCV)–infected patients. However, susceptibility to thrombocytopenia is a major obstacle for initiating or continuing this therapy, particularly in liver transplant (LTx) recipients with HCV.
Upper midline incision for living donor right hepatectomy
Seong Hoon Kim, Seong Yeon Cho, Kwang Woong Lee, Sang‐Jae Park, Sung‐Sik Han – 28 January 2009 – Innovations and refinements in the techniques of living donor right hepatectomy (LDRH) have been made over the past decades, but the type and size of abdominal incision have been at a standstill since its inception. We introduce herein the upper midline incision for LDRH using the standard open technique. A prospective case‐matched study was conducted on 23 consecutive donors who underwent LDRH under a supraumbilical upper midline incision (I group) from February to May 2008.
Knockout of myeloid cell leukemia‐1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes
Binje Vick, Achim Weber, Toni Urbanik, Thorsten Maass, Andreas Teufel, Peter H. Krammer, Joseph T. Opferman, Marcus Schuchmann, Peter R. Galle, Henning Schulze‐Bergkamen – 28 January 2009 – Myeloid cell leukemia‐1 (Mcl‐1) is an antiapoptotic member of the Bcl‐2 protein family. It interacts with proapoptotic Bcl‐2 family members, thereby inhibiting mitochondrial activation and induction of apoptosis. Mcl‐1 is essential for embryonal development and the maintenance of B cells, T cells, and hematopoietic stem cells.
Liver disease as a risk factor for cognitive decline and dementia: An Under‐recognized issue
Yusuf Yilmaz, Osman Ozdogan – 28 January 2009
Hepatitis B virus viral load and treatment decision
Hans Tillmann, Keyur Patel, John McHutchison – 28 January 2009
Reply:
Peter Ferenci – 28 January 2009
The “health” and future of the physician‐scientist in hepatology
Gyongyi Szabo – 28 January 2009
Hepatic function is preserved in the absence of mature microRNAs
Nicholas J. Hand, Zankhana R. Master, John Le Lay, Joshua R. Friedman – 28 January 2009 – MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression through partial or complete complementarity with target messenger RNAs. The function of miRNAs in normal liver physiology is largely unknown. We address the role of Dicer1 in the differentiated liver. We derived mice lacking Dicer1 function in hepatocytes and assessed the loss of mature miRNA via quantitative polymerase chain reaction.
Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant‐dependent manner
Zhi Zhu, Zhigang Luo, Yongmei Li, Canrong Ni, Honghua Li, Minghua Zhu – 28 January 2009 – Inhibitor of growth 1 (ING1) is a type II tumor suppressor that affects cell function by altering chromatin structure and regulating transcription. Recently, three ING1 splice variants have been cloned, but their roles in apoptosis and p53 regulation in human hepatocellular carcinoma (HCC) have not been fully elucidated.