Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment‐naïve patients

Thomas Kuntzen, Joerg Timm, Andrew Berical, Niall Lennon, Aaron M. Berlin, Sarah K. Young, Bongshin Lee, David Heckerman, Jonathan Carlson, Laura L. Reyor, Marianna Kleyman, Cory M. McMahon, Christopher Birch, Julian Schulze zur Wiesch, Timothy Ledlie, Michael Koehrsen, Chinnappa Kodira, Andrew D. Roberts, Georg M. Lauer, Hugo R. Rosen, Florian Bihl, Andreas Cerny, Ulrich Spengler, Zhimin Liu, Arthur Y. Kim, Yanming Xing, Arne Schneidewind, Margaret A. Madey, Jaquelyn F. Fleckenstein, Vicki M. Park, James E. Galagan, Chad Nusbaum, Bruce D. Walker, Gerond V. Lake‐Bakaar, Eric S.

Liver sinusoidal endothelial cells depend on mannose receptor‐mediated recruitment of lysosomal enzymes for normal degradation capacity

Kjetil Elvevold, Jaione Simon‐Santamaria, Hege Hasvold, Peter McCourt, Bård Smedsrød, Karen Kristine Sørensen – 24 November 2008 – Liver sinusoidal endothelial cells (LSECs) are largely responsible for the removal of circulating lysosomal enzymes (LE) via mannose receptor (MR)‐mediated endocytosis. We hypothesized that LSECs rely on this uptake to maintain their extraordinarily high degradation capacity for other endocytosed material.

Ischemic preconditioning of the liver: A few perspectives from the bench to bedside translation

Kunj K. Desai, George S. Dikdan, Asif Shareef, Baburao Koneru – 29 October 2008 – Utilization of ischemic preconditioning to ameliorate ischemia/reperfusion injury has been extensively studied in various organs and species for the past two decades. While hepatic ischemic preconditioning in animals has been largely beneficial, translational efforts in the two clinical contexts—liver resection and decreased donor liver transplantation—have yielded mixed results.

Biliary hemorrhage after removal of an expandable metallic stent during liver transplantation

Shunji Narumi, Kenichi Hakamda, Yoshikazu Toyoki, Keinosuke Ishido, Masaki Nara, Syuichi Yoshihara, Mutsuo Sasaki – 29 October 2008 – The self‐expandable metallic stent (SEMS) has become a common device for palliative treatment of malignant biliary obstructions or benign strictures. Despite the ease of placement of SEMSs, their removal has been reported to be very difficult. Here, we report a case with primary sclerosing cholangitis who developed massive hemorrhage after intraoperative removal of a SEMS.

Use of activated protein c in liver transplantation patients with septic shock

Laura Rinaldi, Marco Marietta, Mariano Alejandro Mignini, Lara Donno, Stefano Busani, Mauro Codeluppi, Michele Masetti, Massimo Girardis – 29 October 2008 – Recombinant human activated protein C (rhAPC) has been approved for use in patients with severe sepsis at high risk of death. Because of the high risk of bleeding, liver transplantation (LT) patients have been excluded from the randomized control trials that evaluated efficacy and safety of rhAPC and, thus, few data are available on the use of this drug in LT patients with severe sepsis.

Graft histology characteristics in long‐term survivors of pediatric liver transplantation

Udeme D. Ekong, Hector Melin‐Aldana, Roopa Seshadri, Joan Lokar, Dave Harris, Peter F. Whitington, Estella M. Alonso – 29 October 2008 – The factors that influence the long‐term histological outcome of transplanted liver allografts in children are not yet fully understood, and the role of surveillance biopsies in patients with normal graft function remains controversial. The aims of this study were to describe the long‐term graft histology of pediatric liver transplant recipients surviving at least 3 years and to analyze factors correlating with long‐term histological outcome.

Subscribe to