Scott L. Friedman, 59th President, AASLD
Meena B. Bansal, Simon W. Beaven, Don C. Rockey – 28 October 2008
Retinol‐binding protein 4 as a circulating marker of hepatic steatosis
Tetsuji Fujita – 28 October 2008
Performance parameters of the diagnostic scoring systems for autoimmune hepatitis
Albert J. Czaja – 28 October 2008 – The diagnostic criteria for autoimmune hepatitis (AIH) have been codified by an international panel, and a revision of the original scoring system based on 12 clinical components has been promulgated. A simplified scoring system has been proposed recently that is based on four clinical components. The goals of this study were to compare the performance parameters of the revised original and the simplified scoring systems and to determine the prowess of each as a diagnostic instrument.
A 20‐year single‐center experience with acute liver failure during pregnancy: Is the prognosis really worse?
Vikram Bhatia, Amit Singhal, Subrat Kumar Panda, Subrat Kumar Acharya – 28 October 2008 – Pregnant patients with acute liver failure (ALF) are believed to have a worse outcome than nonpregnant women and men with ALF. However objective data supporting this supposition are scant. Therefore, the current study compared the outcome, complications, and causes of ALF among pregnant women and girls with age‐matched nonpregnant women and girls and men and boys with ALF.
Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
Yan‐Dong Wang, Wei‐Dong Chen, Meihua Wang, Donna Yu, Barry M. Forman, Wendong Huang – 28 October 2008 – The farnesoid X receptor (FXR) is a nuclear receptor that plays key roles in hepatoprotection by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic inflammation and develop spontaneous liver tumors. In this report, we demonstrate that FXR is a negative modulator of nuclear factor κB (NF‐κB)–mediated hepatic inflammation.
Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay
Marlyn J. Mayo, Julie Parkes, Beverley Adams‐Huet, Burton Combes, A. S. Mills, Rodney S. Markin, Raphael Rubin, Donald Wheeler, Melissa Contos, A. B. West, Sandra Saldana, Yonas Getachew, Robert Butsch, Velimir Luketic, Marion Peters, Adrian Di Bisceglie, Nathan Bass, John Lake, Thomas Boyer, Enrique Martinez, James Boyer, Guadalupe Garcia‐Tsao, David Barnes, William M. Rosenberg – 28 October 2008 – Primary biliary cirrhosis (PBC) is sometimes diagnosed based on a positive antimitochondrial antibody in the appropriate clinical setting without a liver biopsy.
Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase–dependent mechanism
Joy X. Jiang, Kenichiro Mikami, Vijay H. Shah, Natalie J. Torok – 28 October 2008 – Leptin, a profibrogenic cytokine, plays an important role in the development of non‐alcoholic steatohepatitis. Leptin also regulates immune responses, including macrophage phagocytic activity. Stellate cells are key elements in liver fibrogenesis, and previously we have demonstrated that phagocytosis of apoptotic bodies by stellate cells is profibrogenic.
Hepatic vascular malformations in hereditary hemorrhagic telangiectasia: In search of predictors of significant disease
Guadalupe Garcia‐Tsao, Karen L. Swanson – 28 October 2008
Avoiding therapeutic pitfalls: The rational use of specifically targeted agents against hepatitis C infection
Barbara H. McGovern, Barham K. Abu Dayyeh, Raymond T. Chung – 28 October 2008 – The development of specifically targeted antiviral agents against hepatitis C is a major therapeutic advance that promises to markedly improve treatment response rates in patients with chronic infection. However, rapid emergence of drug resistance has already been described, the consequences of which are not yet understood.