Placebo‐controlled trial of 400 mg amantadine combined with peginterferon alfa‐2a and ribavirin for 48 weeks in chronic hepatitis C virus‐1 infection

Michael von Wagner, Wolf Peter Hofmann, Gerlinde Teuber, Thomas Berg, Tobias Goeser, Ulrich Spengler, Holger Hinrichsen, Hans Weidenbach, Guido Gerken, Michael Manns, Peter Buggisch, Eva Herrmann, Stefan Zeuzem – 28 October 2008 – The impact of amantadine on virologic response rates of interferon‐based treatment of chronic hepatitis C is controversial.

Impact of the hepatitis B virus genotype on pre– and post–liver transplantation outcomes

Paul Gaglio, Sundeep Singh, Bulent Degertekin, Michael Ishitani, Munira Hussain, Robert Perrillo, Anna S. Lok – 29 September 2008 – Emerging data suggest that the hepatitis B virus (HBV) genotype and the precore and core promoter variants impact the outcome of orthotopic liver transplantation (OLT) for hepatitis B. The aim of this study was to determine if there is a correlation between HBV genotype, precore and core promoter variants, and pre‐ and post‐OLT outcomes.

Temporary portocaval shunt in orthotopic liver transplantation: Need for a standardized approach?

Diego Davila, Adam Bartlett, Nigel Heaton – 29 September 2008 – Maintenance of portal and systemic venous return during the anhepatic phase of liver transplantation (LT) improves hemodynamic stability. With the piggyback technique, caval return is maintained; however, temporary clamping of the portal vein is still necessary. The use of a temporary portocaval shunt (TPCS) has been proposed to minimize the effect of portal venous interruption.

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