Use of the molecular adsorbents recirculating system as a treatment for acute decompensated wilson disease

Alexander Chiu, Nai Shun Tsoi, Sheung Tat Fan – 29 September 2008 – Acute decompensated Wilson disease presenting as fulminant liver failure is a life‐threatening condition for which liver transplantation is the ultimate treatment. It is listed as a status 1 indication according to the United Network for Organ Sharing classification. A massive amount of copper released during the attack induces hemolytic anemia and acute renal failure.

Detection and diagnosis of herpes simplex virus infection in adults with acute liver failure

Josh Levitsky, Anupama T. Duddempudi, Fred D. Lakeman, Richard J. Whitley, James P. Luby, William M. Lee, Robert J. Fontana, Andres T. Blei, Michael G. Ison – 29 September 2008 – Disseminated herpes simplex virus (HSV) infection may lead to acute liver failure (ALF) and the need for emergency liver transplantation (LT). The primary aim of this study was to determine the utility of HSV serological testing and HSV DNA testing by polymerase chain reaction (PCR) in the diagnosis and management of indeterminate, pregnancy‐related, and known HSV‐related ALF.

Biliary cast syndrome following liver transplantation: Predictive factors and clinical outcomes

Niraj V. Gor, Ronald M. Levy, Joseph Ahn, Dmitriy Kogan, S. Forrest Dodson, Stanley Martin Cohen – 29 September 2008 – Biliary cast syndrome (BCS), the presence of biliary casts and debris causing biliary obstruction, occurs in 4%‐18% of orthotopic liver transplant (OLT) recipients. Potential consequences include cholangitis and graft damage or loss. Limited data exist regarding the etiology and outcomes of BCS. The purpose of this study was to evaluate donor and recipient risk factors and determine the impact of BCS.

Risk of malignant neoplasms after liver transplantation: A population‐based study

Fredrik Åberg, Eero Pukkala, Krister Höckerstedt, Risto Sankila, Helena Isoniemi – 29 September 2008 – Posttransplant malignancies have become a serious long‐term complication after liver transplantation. Our aim was to compare the incidence of posttransplant cancers with national cancer incidence rates. The study included all Finnish liver transplant patients transplanted at the Helsinki University Central Hospital between 1982 and 2005. The cohort was linked with the nationwide Finnish Cancer Registry.

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