Vasopressin decreases portal vein pressure and flow in the native liver during liver transplantation

Gebhard Wagener, Gina Gubitosa, John Renz, Milan Kinkhabwala, Tricia Brentjens, James V. Guarrera, Jean Emond, H. Thomas Lee, Donald Landry – 29 October 2008 – Vasodilation due to impaired vascular tone is common in liver failure. Vasoconstrictor drugs are almost always required during the anhepatic phase of a liver transplant to maintain blood pressure unless venovenous bypass is employed.

Liver tumors: Pediatric population

Milton J. Finegold, Rachel A. Egler, John A. Goss, R. Paul Guillerman, Saul J. Karpen, Rajesh Krishnamurthy, Christine Ann O'Mahony – 29 October 2008 – Liver tumors in childhood are rare and are typically not detected clinically until they reach a large size and often spread within the organ or metastasize. This can make surgical resection problematic, and almost all of them require extirpation for cure.

Graft histology characteristics in long‐term survivors of pediatric liver transplantation

Udeme D. Ekong, Hector Melin‐Aldana, Roopa Seshadri, Joan Lokar, Dave Harris, Peter F. Whitington, Estella M. Alonso – 29 October 2008 – The factors that influence the long‐term histological outcome of transplanted liver allografts in children are not yet fully understood, and the role of surveillance biopsies in patients with normal graft function remains controversial. The aims of this study were to describe the long‐term graft histology of pediatric liver transplant recipients surviving at least 3 years and to analyze factors correlating with long‐term histological outcome.

Use of activated protein c in liver transplantation patients with septic shock

Laura Rinaldi, Marco Marietta, Mariano Alejandro Mignini, Lara Donno, Stefano Busani, Mauro Codeluppi, Michele Masetti, Massimo Girardis – 29 October 2008 – Recombinant human activated protein C (rhAPC) has been approved for use in patients with severe sepsis at high risk of death. Because of the high risk of bleeding, liver transplantation (LT) patients have been excluded from the randomized control trials that evaluated efficacy and safety of rhAPC and, thus, few data are available on the use of this drug in LT patients with severe sepsis.

Biliary hemorrhage after removal of an expandable metallic stent during liver transplantation

Shunji Narumi, Kenichi Hakamda, Yoshikazu Toyoki, Keinosuke Ishido, Masaki Nara, Syuichi Yoshihara, Mutsuo Sasaki – 29 October 2008 – The self‐expandable metallic stent (SEMS) has become a common device for palliative treatment of malignant biliary obstructions or benign strictures. Despite the ease of placement of SEMSs, their removal has been reported to be very difficult. Here, we report a case with primary sclerosing cholangitis who developed massive hemorrhage after intraoperative removal of a SEMS.

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