The clinical and physiological spectrum of interferon‐alpha induced thyroiditis: Toward a new classification

Jamie C. Mandac, Sonal Chaudhry, Kenneth E. Sherman, Yaron Tomer – 23 March 2006 – Interferon‐alpha (IFNα) is a major treatment modality for several malignant and nonmalignant diseases, especially hepatitis C. Prospective studies have shown that up to 15% of patients with hepatitis C receiving IFNα develop clinical thyroid disease, and up to 40% were reported to develop thyroid antibodies. Some of these complications may result in discontinuation of interferon therapy. Thus, interferon induced thyroiditis (IIT) is a major clinical problem for patients receiving interferon therapy.

The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: An analysis of the OPTN database

Victor Navarro, Steven Herrine, Charles Katopes, Beth Colombe, C. Victor Spain – 22 March 2006 – The purpose of this study was to explore the relationship between human leukocyte antigen (HLA) compatibility and liver transplantation outcomes by analyzing the effect of HLA compatibility on 5‐year graft survival. We analyzed first liver transplants between 1987 and 2002 in the Organ Procurement and Transplantation Network (OPTN) database, where A, B, or DR loci data were available. Graft failure was defined as retransplantation or death from transplant‐related cause.

Influence of donor/recipient HLA‐matching on outcome and recurrence of hepatitis C after liver transplantation

Jan Michael Langrehr, Gero Puhl, Marcus Bahra, Maximilian Schmeding, Antonino Spinelli, Thomas Berg, Constanze Schönemann, Veit Krenn, Peter Neuhaus, Ulf Peter Neumann – 22 March 2006 – The aim of this study was to analyze the effect of human leukocyte antigen (HLA) matching on outcome, severity of recurrent hepatitis C and risk of rejection in hepatitis C positive patients after liver transplantation (LT).

Disseminated histoplasmosis in a liver transplant recipient

Young S. Oh, Mauricio Lisker‐Melman, Kevin M. Korenblat, Gary R. Zuckerman, Jeffrey S. Crippin – 22 March 2006 – A 61‐yr‐old liver transplant recipient presented with abdominal cramping and nonbloody diarrhea resulting in orthostasis. Multiple ulcerations throughout the colon were seen during endoscopy, and biopsies from the ulcer edges revealed histoplasmosis. Treatment with a course of itraconazole improved the diarrhea. The patient later presented with pericarditis and symptomatic pleural effusions, the latter of which was confirmed to be a result of disseminated histoplasmosis.

Value of dobutamine stress myocardial contrast perfusion echocardiography in patients with advanced liver disease

Jeane M. Tsutsui, Sandeep Mukherjee, Abdou Elhendy, Feng Xie, Elizabeth R. Lyden, Edward O'Leary, Anna C. McGrain, Thomas R. Porter – 22 March 2006 – Although dobutamine stress echocardiography has been used for the preoperative evaluation of patients with advanced liver disease (ALD), no data exist regarding the value of myocardial perfusion imaging (MPI) with real‐time myocardial contrast echocardiography (RTMCE) in this patient population. We sought to determine the value of MPI during dobutamine stress RTMCE for predicting prognosis in patients with ALD.

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