Fetal and infantile hemochromatosis
Peter F. Whitington – 23 March 2006
Intestinal mucosal alterations in rats with carbon tetrachloride‐induced cirrhosis: Changes in glycosylation and luminal bacteria
Sathish Kumar Natarajan, Prabhu Ramamoorthy, Simmy Thomas, Jayasree Basivireddy, Gagandeep Kang, Anup Ramachandran, Anna B Pulimood, K.A. Balasubramanian – 23 March 2006 – Spontaneous bacterial peritonitis is a major cause of mortality after liver cirrhosis. Altered permeability of the mucosa and deficiencies in host immune defenses through bacterial translocation from the intestine due to intestinal bacterial overgrowth have been implicated in the development of this complication. Molecular mechanisms underlying the process are not well known.
Steatosis and progression of fibrosis in untreated patients with chronic hepatitis C infection
Ponni Perumalswami, David E. Kleiner, Glen Lutchman, Theo Heller, Brian Borg, Yoon Park, T. Jake Liang, Jay H. Hoofnagle, Marc G. Ghany – 23 March 2006 – Hepatic steatosis is common in patients with chronic hepatitis C (CHC) and is reported to be a risk factor for progression of fibrosis. The aims of this study were to evaluate the interactions between hepatic steatosis and fibrosis in a well‐defined cohort of patients with CHC.
Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock
Ming‐Hung Tsai, Yun‐Shing Peng, Yung‐Chang Chen, Nai‐Jeng Liu, Yu‐Pin Ho, Ji‐Tseng Fang, Jau‐Min Lien, Chun Yang, Pang‐Chi Chen, Cheng‐Shyong Wu – 23 March 2006 – Patients with cirrhosis are susceptible to bacterial infection, which can result in circulatory dysfunction, renal failure, hepatic encephalopathy, and a decreased survival rate. Severe sepsis is frequently associated with adrenal insufficiency, which may lead to hemodynamic instabity and a poor prognosis.
Intermittent disconjugate gaze: A novel finding in nonalcoholic steatohepatitis
Jerome Schartman, Joel Weinstein – 23 March 2006
Attenuated liver fibrosis in the absence of B cells
Andrew P. Holt, Zania Stamataki, David H. Adams – 23 March 2006
Intrahepatic cholestasis of pregnancy — A heterogeneous group of pregnancy‐related disorders?
Ulrich Beuers, Thomas Pusl – 23 March 2006
Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study
William J. Holubek, Susanne Kalman, Robert S. Hoffman – 23 March 2006
Mechanisms of alcohol‐induced hepatic fibrosis: A summary of the Ron Thurman Symposium
Vishnudutt Purohit, David A. Brenner – 23 March 2006 – This report is a summary of Ron Thurman Symposium on the Mechanisms of Alcohol‐Induced Hepatic Fibrosis which was organized by The National Institutes of Health in Santa Barbara, California, June 25, 2005. The Symposium and this report highlight the unique aspects by which drinking alcoholic beverages may result in hepatic fibrosis. Acetaldehyde, the first metabolite of ethanol, can upregulate transcription of collagen I directly as well as indirectly by upregulating the synthesis of transforming growth factor‐beta 1 (TGF‐β1).
Liver‐targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis
Ruth Y. Lan, Chunmei Cheng, Zhe‐Xiong Lian, Koichi Tsuneyama, Guo‐Xiang Yang, Yuki Moritoki, Ya‐Hui Chuang, Takafumi Nakamura, Shigeru Saito, Shinji Shimoda, Atsushi Tanaka, Christopher L. Bowlus, Yasuo Takano, Aftab A. Ansari, Ross L. Coppel, M. Eric Gershwin – 23 March 2006 – CD4+CD25high regulatory T cells (Tregs) play a critical role in self‐tolerance, as seen in murine autoimmunity. Studies on Tregs in human autoimmunity have focused primarily on peripheral blood samples. A study targeting diseased tissue should identify direct relationships between Tregs and autoimmunity.