Katja Derkow, Christoph Loddenkemper, Justine Mintern, Nils Kruse, Katja Klugewitz, Thomas Berg, Bertram Wiedenmann, Hidde L. Ploegh, Eckart Schott – 26 July 2007 – The pathogenesis of autoimmune liver diseases is poorly understood. Animal models are necessary to investigate antigen presentation and priming of T‐cells in the context of autoimmunity in the liver. Transgenic mouse models were generated in which the model antigen ovalbumin is expressed in hepatocytes (TF‐OVA) or cholangiocytes (ASBT‐OVA).

Yen‐Shen Lu, Yoko Kashida, Samuel K. Kulp, Yu‐Chieh Wang, Dasheng Wang, Jui‐Hsiang Hung, Monica Tang, Zhong‐Zhe Lin, Te‐Jung Chen, Ann‐Lii Cheng, Ching‐Shih Chen – 25 July 2007 – Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, yet effective therapeutic options for advanced HCC are limited. This study was aimed at assessing the antitumor effect of a novel phenylbutyrate‐derived histone deacetylase (HDAC) inhibitor, OSU‐HDAC42, vis‐à‐vis suberoylanilide hydroxamic acid (SAHA), in in vitro and in vivo models of human HCC.

Patricia E. Ganey, James P. Luyendyk, Sandra W. Newport, Theresa M. Eagle, Jane F. Maddox, Nigel Mackman, Robert A. Roth – 25 July 2007 – Acetaminophen (N‐acetyl‐p‐aminophenol [APAP]) is one of the leading causes of acute liver failure, and APAP hepatotoxicity is associated with coagulopathy in humans. We tested the hypothesis that activation of the coagulation system and downstream protease‐activated receptor (PAR)‐1 signaling contribute to APAP‐induced liver injury.

Jordan J. Feld, Melissa Ayers, Dahlia El‐Ashry, Tony Mazzulli, Raymond Tellier, E. Jenny Heathcote – 25 July 2007 – After hepatitis B e antigen (HBeAg) seroconversion, hepatitis B may become inactive or progress to HBeAg‐negative hepatitis with persistent or intermittent alanine aminotransferase (ALT) elevation. The aim of this study was to prospectively identify factors predictive of the clinical course in HBeAg‐negative chronic hepatitis B (CHB). Patients were stratified by ALT and HBeAg status and followed every 3 months for up to 5 years.

Puneet Puri, Rebecca A. Baillie, Michelle M. Wiest, Faridoddin Mirshahi, Jayanta Choudhury, Onpan Cheung, Carol Sargeant, Melissa J. Contos, Arun J. Sanyal – 25 July 2007 – The spectrum of nonalcoholic fatty liver disease (NAFLD) includes a nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The specific types and amounts of lipids that accumulate in NAFLD are not fully defined.

Maureen M. J. Guichelaar, Jeffrey Schmoll, Michael Malinchoc, J. Eileen Hay – 25 July 2007 – With early posttransplant bone loss, orthotopic liver transplantation (OLT) recipients experience a high rate of fracturing and some avascular necrosis (AVN), but little is known about the incidence of and predictive factors for these skeletal complications.

25 July 2007

Steven Y. Lin, Ellen T. Chang, Samuel K. So – 24 July 2007 – Chronic hepatitis B virus (HBV) infection is a serious liver disease that, if left undiagnosed or without appropriate medical management, is associated with a 25% chance of death from cirrhosis or liver cancer. To study the demographics and prevalence of chronic HBV infection and HBV vaccination in the Asian American population, we provided free HBV serological screening and administered a survey to 3163 Asian American adult volunteers in the San Francisco Bay Area between 2001 and 2006.

Mercedes Fernandez, Marc Mejias, Ester Garcia‐Pras, Raul Mendez, Juan Carlos Garcia‐Pagan, Jaime Bosch – 24 July 2007 – Vascular endothelial growth factor (VEGF) and platelet‐derived growth factor (PDGF) pathways are crucial to angiogenesis, a process that contributes significantly to the pathogenesis of portal hypertension. This study determined the effects of inhibition of VEGF and/or PDGF signaling on hyperdynamic splanchnic circulation and portosystemic collateralization in rats with completely established portal hypertension, thus mimicking the situation in patients.

Byung Chul Yoo, Ju Hyun Kim, Tae‐Hun Kim, Kwang Cheol Koh, Soon‐Ho Um, Young Soo Kim, Kwan Sik Lee, Byung Hoon Han, Chae Yoon Chon, Joon‐Yeol Han, Soo Hyung Ryu, Haak Cheoul Kim, Kwan Soo Byun, Seong Gyu Hwang, Byung‐Ik Kim, Mong Cho, Kwon Yoo, Heon‐Ju Lee, Jae Seok Hwang, Yun Soo Kim, Young‐Suk Lee, Sung‐Kyu Choi, Youn‐Jae Lee, Jin‐Mo Yang, Joong‐Won Park, Myung‐Seok Lee, Dae‐Ghon Kim, Young‐Hwa Chung, Se‐Hyun Cho, Jong‐Young Choi, Young‐Oh Kweon, Heon Young Lee, Sook‐Hyang Jeong, Hee‐Won Yoo, Hyo‐Suk Lee – 23 July 2007 – Clevudine is a pyrimidine analog with potent and sustained antiviral