Impact of implementation of the MELD scoring system on the prevalence and incidence of chronic renal disease following liver transplantation

Victor I. Machicao, Titte R. Srinivas, Alan W. Hemming, Consuelo Soldevila‐Pico, Roberto J. Firpi, Alan I. Reed, Giuseppi J. Morelli, David R. Nelson, Manal F. Abdelmalek – 9 March 2006 – The implementation of the model for end‐stage liver disease (MELD) score decreased mortality of those awaiting liver transplantation (LT); however, the impact of the MELD allocation system on the risk of chronic renal disease after LT remains unknown. We conducted a non‐concurrent single‐center cohort study of 174 patients undergoing LT at our center.

Long‐term incidence, risk factors, and management of biliary complications after adult living donor liver transplantation

Shin Hwang, Sung‐Gyu Lee, Kyu‐Bo Sung, Kwang‐Min Park, Ki‐Hun Kim, Chul‐Soo Ahn, Young‐Joo Lee, Sung‐Koo Lee, Gyu‐Sam Hwang, Deok‐Bog Moon, Tae‐Yong Ha, Dong‐Sik Kim, Jae‐Pil Jung, Gi‐Won Song – 9 March 2006 – A considerable proportion of adult living donor liver transplantation (LDLT) recipients experience biliary complication (BC), but there are few reports regarding BC based on long‐term studies of a large LDLT population.

Isolation of hepatocytes from livers from non‐heart‐beating donors for cell transplantation

Robin D. Hughes, Ragai R. Mitry, Anil Dhawan, Sharon C. Lehec, Raffaele Girlanda, Mohamed Rela, Nigel D. Heaton, Paolo Muiesan – 9 March 2006 – One of the limitations to hepatocyte transplantation is the restricted availability of donor liver tissue. The aim of this study was to evaluate livers from non‐heart‐beating donors (NHBDs) as a source of hepatocytes for cell transplantation. A total of 20 livers/segments obtained from NHBD were perfused under good manufacturing practices using a standard collagenase digestion method.

Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival

Frederike G.I. van Vilsteren, Edwina S. Baskin‐Bey, David M. Nagorney, Schuyler O. Sanderson, Walter K. Kremers, Charles B. Rosen, Gregory J. Gores, Timothy J. Hobday – 23 February 2006 – Liver transplantation for gastroenteropancreatic neuroendocrine cancer (GEP) is controversial. The aim of this study was to assess patient outcomes after liver transplantation for hepatic metastases from GEP. Medical records of patients who underwent liver transplantation for GEP were reviewed. Immunohistochemistry for assessing the Ki67 proliferation index was performed on explanted liver tissue.

Thrombopoietin in postoperative thrombocytopenia following living donor hepatectomy

Yoshihide Nagasako, Meang Bong Jin, Hiroshi Miyazaki, Masato Nakayama, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michiaki Matushita, Satoru Todo – 23 February 2006 – Thrombocytopenia is a frequent finding following living donor hepatectomy. It appears more pronounced in right graft donors than in left graft donors. This study analyzed postoperative thrombocytopenia in 20 living liver donors and examined the change of endogenous thrombopoietin (TPO) in its recovery.

Interventional radiology in liver transplantation

Nikhil B. Amesur, Albert B. Zajko – 23 February 2006 – Improvements in surgical technique, advances in the field of immunosuppresion and the early diagnosis and treatment of complications related to liver transplantation have all led to prolonged survival after liver transplantation. In particular, advances in diagnostic and interventional radiology have allowed the Interventional Radiologist, as part of the transplant team, to intervene early in patients presenting with complications related to organ transplant with resultant increase in graft and patient survival.

Regional sharing for adult status 1 candidates: Reduction in waitlist mortality

Kenneth Washburn, Ann Harper, Goran Klintmalm, John Goss, Glenn Halff – 23 February 2006 – The intent of regional sharing for status 1 candidates is to promote timely access to donor livers. Presumably this decreases waitlist mortality. Little published data exists that supports this policy. Organ Procurement and Transplantation Network data was used to calculate region 4 and national adult waitlist death and transplant rates 4 yr prior to (period A) and after (period B) implementation of the sharing agreement in July 1999.

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