Highlights in Liver Transplantation
28 November 2006
Liver sinusoidal endothelial cells: Their unique role in immune tolerance
James D. Perkins – 28 November 2006
Neoadjuvant therapies for hepatocellular carcinoma before liver transplantation: A critical appraisal
Patricia M. Lopez, Augusto Villanueva, Sasan Roayaie, Josep M. Llovet – 28 November 2006
Conversion to sirolimus: A useful strategy for recalcitrant cutaneous viral warts in liver transplant recipient
Sébastien Dharancy, Benoît Catteau, Laurent Mortier, Emmanuel Boleslawski, Nicole Declerck, Valérie Canva, Frédéric Piette, Philippe Mathurin, François René Pruvot – 28 November 2006 – Dermatological complications following transplantation are very common and the majority of immunosuppressed transplant recipients develop some to many warts due to human papillomavirus (HPV) infection. In the setting of immunosuppression, therapeutic management may be disappointing because of the extent of the lesions in patients unable to develop a sufficient immune response directed against HPV.
Relative adrenal insufficiency manifested with multiple organ dysfunction in a liver transplant patient
Takeshi Iwasaki, Masahiro Tominaga, Takumi Fukumoto, Nobuya Kusunoki, Takemi Sugimoto, Masahiro Kido, Satoshi Ogata, Atsushi Takebe, Motofumi Tanaka, Yonson Ku – 28 November 2006 – Relative adrenal insufficiency is now a well‐known clinical condition that occurs in critically ill patients particularly with septic complication. However, this pathology has long been unrecognized until recently in liver transplantation patients, for whom postoperative immunosuppressive therapies almost always comprise corticosteroids.
In vivo expansion of two distinct dendritic cells in mouse livers and its impact on liver immune regulation
Yalan Wang, Ning Zheng, Zhengbin Lu, Wenhan Wu, Lianfu Wang, Atsunori Nakao, Michael T. Lotze, Carrie E. Langer, John J. Fung, Shiguang Qian, Lina Lu – 28 November 2006 – Liver transplant tolerance in pigs, rats, and mice has been disclosed for decades, but the underlying mechanisms are not completely understood. Accumulating data indicate that residing dendritic cells (DC) are important in determining direction of immune responses in the liver. However, our knowledge remains very limited due to the difficulties in obtaining sufficient liver DC.
The role of oxidative stress and antioxidant treatment in liver surgery and transplantation
Tom Luedde, Christian Trautwein – 28 November 2006
Growth factors during HCV therapy may be “cost‐effective”, but are they “effective”?
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Andrew J. Muir, John G. McHutchison – 28 November 2006
IP‐10 predicts viral response and therapeutic outcome in difficult‐to‐treat patients with HCV genotype 1 infection
Martin Lagging, Ana I. Romero, Johan Westin, Gunnar Norkrans, Amar P. Dhillon, Jean‐Michel Pawlotsky, Stefan Zeuzem, Michael von Wagner, Francesco Negro, Solko W. Schalm, Bart L. Haagmans, Carlo Ferrari, Gabriele Missale, Avidan U. Neumann, Elke Verheij‐Hart, Kristoffer Hellstrand, DITTO‐HCV Study Group – 28 November 2006 – Plasma from 173 patients with HCV genotype 1 infection was analyzed for IP‐10 levels prior to treatment with pegylated interferon‐α‐2a and ribavirin.
Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: Lessons from the HALT‐C trial
Gregory T. Everson, John C. Hoefs, Leonard B. Seeff, Herbert L. Bonkovsky, Deepa Naishadham, Mitchell L. Shiffman, Jeffrey A. Kahn, Anna S. F. Lok, Adrian M. Di Bisceglie, William M. Lee, Jules L. Dienstag, Marc G. Ghany, Chihiro Morishima, HALT‐C Trial Group – 28 November 2006 – In patients with chronic hepatitis C, advanced fibrosis and cirrhosis are associated with lower rates of sustained virologic response (SVR) to interferon (IFN)‐based therapy.