Claudia Zwingmann, Marc Bilodeau – 22 February 2006 – The hepatoprotective mechanisms of N‐acetylcysteine (NAC) in non–acetaminophen‐induced liver injury have not been studied in detail. We investigated the possibility that NAC could affect key pathways of hepatocellular metabolism with or without changes in glutathione (GSH) synthesis. Hepatocellular metabolites and high‐energy phosphates were quantified from mouse liver extracts by 1H‐ and 31P‐NMR (nuclear magnetic resonance) spectroscopy.

Peter A Bonis, Marshall Kaplan – 22 February 2006

Adrian Reuben – 22 February 2006

Jérôme Dumortier, Sophie Bernard, Yves Bouffard, Olivier Boillot – 22 February 2006 – Adverse effects associated with calcineurin inhibitors may impact their clinical utility in some patients. This study characterizes the clinical outcomes of liver transplanted (LT) patients who experienced diabetes mellitus (DM) on tacrolimus‐based regimen and were converted to cyclosporine‐based therapy. Since January 2002, all patients with DM on a tacrolimus‐based regimen were recruited and converted to cyclosporine‐based therapy, after a 6‐month minimal follow‐up after LT.

Gary A. Levy, Gord Adamson, M. James Phillips, Louise A. Scrocchi, Laisum Fung, Pieter Biessels, Nancy F. Ng, Anand Ghanekar, Andrea Rowe, Max Xuezhong Ma, Adam Levy, Cheryl Koscik, William He, Reginald Gorczynski, Steve Brookes, Caroline Woods, Ian D. McGilvray, David Bell – 22 February 2006 – Side effects of interferon–ribavirin combination therapy limit the sustained viral response achievable in hepatitis C virus (HCV) patients. Coupling ribavirin to macromolecular carriers that target the drug to the liver would reduce systemic complications.

Manuel Hernández‐Guerra, Juan C. García‐Pagán, Juan Turnes, Pablo Bellot, Ramón Deulofeu, Juan G. Abraldes, Jaime Bosch – 22 February 2006 – Patients with cirrhosis show intrahepatic endothelial dysfunction, characterized by an impaired flow‐dependent vasorelaxation. This alteration is responsible for the marked postprandial increase in portal pressure and is attributed to an insufficient release of nitric oxide (NO).

Nicole Appel, Ralf Bartenschlager – 22 February 2006 – MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression. MicroRNA 122 (miR‐122) is specifically expressed and highly abundant in the human liver. We show that the sequestration of miR‐122 in liver cells results in marked loss of autonomously replicating hepatitis C viral RNAs. A genetic interaction between miR‐122 and the 5′ noncoding region of the viral genome was revealed by mutational analyses of the predicted microRNA binding site and ectopic expression of miR‐122 molecules containing compensatory mutations.

Richard Moreau, Didier Lebrec – 22 February 2006 – In patients with cirrhosis and type 1 hepatorenal syndrome (HRS), systemic vasodilation, which is mainly attributable to splanchnic vasodilation, plays a critical role in the activation of endogenous vasoconstrictor systems, resulting in renal vasoconstriction and functional renal failure. It has been suggested that the use of splanchnic (and systemic) vasoconstrictors such as terlipressin (a vasopressin analog) or alpha‐1‐adrenoceptor agonists (midodrine or noradrenaline) may improve renal function in patients with type 1 HRS.

Knut Stokkeland, Lena Brandt, Anders Ekbom, Rolf Hultcrantz – 22 February 2006 – Liver cirrhosis may be complicated by the development of esophageal varices. The treatment of esophageal varices has changed radically during the last 30 years. Our aim was to study whether the prognosis for patients with esophageal varices had improved in Sweden between 1969 and 2002.

David E.J. Jones, Neeraj Bhala, Julia L. Newton – 22 February 2006