Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis

Pierre J. Zindy, Annie L'Helgoualc'h, Dominique Bonnier, Antony Le Béchec, Katia Bourd‐Boitin, Chang Xian Zhang, Orlando Musso, Denise Glaise, Marie Bérangère Troadec, Olivier Loréal, Bruno Turlin, Jean Léger, Bruno Clément, Nathalie Théret – 20 October 2006 – The molecular mechanisms underlying the progression of cirrhosis toward hepatocellular carcinoma were investigated by a combination of DNA microarray analysis and literature data mining.

Fluordeoxyglucose positron emission tomography contributes to management of pediatric liver transplantation candidates with fever of unknown origin

Ekkehard Sturm, Edmond H.H.M. Rings, Elisabeth H. Schölvinck, Annette S.H. Gouw, Robert J. Porte, Jan Pruim – 20 October 2006 – Fever of unknown origin (FUO) frequently complicates the management of pediatric patients with terminal chronic liver failure during the pretransplantation period and may lead to increased morbidity and mortality. Nonhepatic origins of systemic infections may render the patient unsuitable for transplantation whereas infections within the liver may require organ resection for a cure.

Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice

Weiqing Tang, Yinyan Ma, Liqing Yu – 20 October 2006 – Interindividual variation exists in response to statin therapy. It has been hypothesized that subjects with higher baseline cholesterol synthesis rates are more sensitive to statins. To directly test this hypothesis, mice overexpressing the heterodimeric ATP‐binding cassette (ABC) transporter G5/G8 (G5G8Tg mice) were treated with lovastatin because they have a compensatory increase in cholesterol biosynthesis as a result of increased cholesterol excretion into bile and feces.

Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas

Yoh Zen, Takahiko Fujii, Keita Itatsu, Koichi Nakamura, Hiroshi Minato, Satomi Kasashima, Hiroshi Kurumaya, Kazuyoshi Katayanagi, Atsuhiro Kawashima, Shinji Masuda, Hideki Niwa, Takeshi Mitsui, Yasuyuki Asada, Shouji Miura, Tetsuo Ohta, Yasuni Nakanuma – 20 October 2006 – Recently, attention has been drawn to papillary neoplasm of the pancreatobiliary systems. In the pancreas, the disease entity of intraductal papillary mucinous neoplasm (IPMN‐P) is widely recognized.

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