Systemic fungemia and hepatic localizations of Fusarium solani in a liver transplanted patient: An emerging fungal agent

Francesca Lodato, Maria Rosa Tamé, Marco Montagnani, Vittorio Sambri, Giovanna Liguori, Francesco Azzaroli, Paolo Costigliola, Gianluca Grazi, Enrico Roda, Giuseppe Mazzella – 20 October 2006 – The incidence of invasive fungal infection is increasing especially in the field of transplantation, affecting as many as 50% of bone marrow transplant (BMT) patients with neutropenia and 5‐20% of solid‐organ transplant (SOT) recipients. Fusarium species are soil saprophytes and plant pathogens.

Hepatitis C virus reinfection in injection drug users

Jason Grebely, Brian Conway, Jesse D. Raffa, Calvin Lai, Mel Krajden, Mark W. Tyndall – 20 October 2006 – Spontaneous clearance of hepatitis C (HCV) may provide protection against reinfection. In a large community‐based cohort study of 3,553 inner‐city residents (mainly injection drug users), we identified HCV‐infected individuals in whom virological clearance had occurred and compared the rate of reinfection in this group with that observed in previously uninfected members of the same cohort.

Budd‐Chiari syndrome: Radiologic findings

Patrick S. Kamath – 18 October 2006 – Key Concepts: 1Diagnosis of Budd‐Chiari syndrome can be made on the basis of radiological imaging alone without the need for liver biopsy.2Ultrasonography, computed tomography, and magnetic resonance imaging all show various degrees of occlusion of the hepatic veins and/or inferior vena cava. Hypertrophy of the caudate lobe may also be seen.3Computed tomographic and magnetic resonance imaging give a better idea of hepatic perfusion.

Recurrent primary sclerosing cholangitis: Clinical diagnosis and long‐term management issues

Fredric Gordon – 18 October 2006 – Key Concepts: 1Primary sclerosing cholangitis (PSC) in the nontransplant setting is a chronic, progressive liver disease characterized by diffuse stricturing of the biliary tree, cholestatic liver enzymes, and a compatible liver biopsy.2Cholangiography reveals irregularity of the bile duct wall, strictures, beading, and diverticula.3The typical biopsy reveals inflammation and fibrosis of the interlobular and septal bile ducts, often with obliteration or biliary‐type cirrhosis.4The precise pathogenetic mechanism remains elusive but is assumed to be an autoi

A difficult case of primary sclerosing cholangitis

Hugo E. Vargas – 18 October 2006 – Key Concepts: 1The immediate postoperative concerns in a patient with primary sclerosing cholangitis.2Recognize the difficulties in assessing biliary health in patients that have had complicated postoperative biliary concerns.3Recognize the difficulty in ascertaining the presence of chronic rejection vs. recurrent primary sclerosing cholangitis. Liver Transpl. 12:S65–S67. 2006. © 2006 AASLD.

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