Harmeet Malhi, Gregory J. Gores, John J. Lemasters – 30 January 2006 – Death of hepatocytes and other hepatic cell types is a characteristic feature of liver diseases as diverse as cholestasis, viral hepatitis, ischemia/reperfusion, liver preservation for transplantation and drug/toxicant‐induced injury. Cell death typically follows one of two patterns: oncotic necrosis and apoptosis. Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion as occurs in ischemia/reperfusion and acute drug‐induced hepatotoxicity.

Vito Racanelli, Barbara Rehermann – 30 January 2006 – The liver is a unique anatomical and immunological site in which antigen‐rich blood from the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen‐presenting cells and lymphocytes. The liver's lymphocyte population is selectively enriched in natural killer and natural killer T cells which play critical roles in first line immune defense against invading pathogens, modulation of liver injury and recruitment of circulating lymphocytes.

Dr. Andres T. Blei – 30 January 2006

Yasuko Iwakiri, Roberto J. Groszmann – 30 January 2006 – The hyperdynamic circulatory syndrome observed in chronic liver diseases is a great example of research that originated from clinical observations and progressed in the last 50 years from the patient to the experimental laboratory. Our knowledge has evolved from the patient to the molecule, using experimental models that serve as a source for understanding the complex pathophysiological mechanisms that govern this complex syndrome.

Nelson Fausto, Jean S. Campbell, Kimberly J. Riehle – 30 January 2006 – During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo one or two rounds of replication to restore the liver mass by a process of compensatory hyperplasia. A large number of genes are involved in liver regeneration, but the essential circuitry required for the process may be categorized into three networks: cytokine, growth factor and metabolic. There is much redundancy within each network, and intricate interactions exist between them.

Neil Kaplowitz – 30 January 2006

30 January 2006

Michael Charlton – 30 January 2006

David L. Thomas – 30 January 2006 – Liver disease is a growing problem in HIV‐infected persons. In those who are able to take antiretroviral therapy, the forms of liver disease have changed and their relative importance has increased. This review focuses on liver disease in HIV‐infected persons, caused by hepatitis C virus, hepatitis B virus, or treatment of HIV infection. (Hepatology 2006;43:S221–S229.)

Adrian Reuben – 30 January 2006