Pamela Vig, Francesco P. Russo, Robert J. Edwards, Paul J. Tadrous, Nicholas A. Wright, Howard C. Thomas, Malcolm R. Alison, Stuart J. Forbes – 26 January 2006 – After liver injury, parenchymal regeneration occurs through hepatocyte replication. However, during regenerative stress, oval cells (OCs) and small hepatocyte like progenitor cells (SHPCs) contribute to the process. We systematically studied the intra‐hepatic and extra‐hepatic sources of liver cell replacement in the hepatitis B surface antigen (HBsAg‐tg) mouse model of chronic liver injury.

Briana M. Erickson, Nancy L. Thompson, Douglas C. Hixson – 26 January 2006 – TuAg1/TagE4, the rat ortholog of the human poliovirus receptor CD155, is expressed on a high percentage of rat hepatocellular carcinomas. Recent studies have shown that TuAg1/TagE4/CD155 is a member of the nectin family of immunoglobulin (Ig)‐like cell adhesion molecules, designated necl‐5. Necl‐5 is present at exceedingly low levels in adult epithelial tissues but is upregulated in primary cultures of rat hepatocytes, suggesting that disruption of liver architecture triggers its expression.

Lori R. Bernstein – 26 January 2006

Carolin Lackner, Gerd Struber, Csilla Bankuti, Bernd Bauer, Rudolf E. Stauber – 26 January 2006

Fabrice Lainé, Claude Bendavid, Jeff Morcet, Michéle Perrin, Catherine Massart, Yves Deugnier – 26 January 2006

Keyur Patel, Suzanne Norris, Lauralynn Lebeck, Anne Feng, Michael Clare, Stephen Pianko, Bernard Portmann, Lawrence M. Blatt, James Koziol, Andrew Conrad, John G. McHutchison – 26 January 2006 – Patients infected with HIV‐1 who are heterozygous at HLA class I loci present greater variety of antigenic peptides to CD8+ cytotoxic T lymphocytes, slowing progression to AIDS. A similar broad immune response in chronic hepatitis C (CHC) infection could result in greater hepatic injury.

Thierry Poynard, Mona Munteanu, Yen Ngo, Mercedes Torres, Yves Benhamou, Dominique Thabut, Vlad Ratziu – 26 January 2006

Kymberly D.S. Watt, Elizabeth R. Lyden, James M. Gulizia, Timothy M. McCashland – 28 December 2005 – Organ cold/warm ischemia is thought to be a risk factor for increased severity of recurrence of hepatitis C (HCV) post liver transplantation. We had noted some HCV patients with preservation injury (PI) to have particularly poor outcomes. Our goal was to determine if PI on biopsy in HCV patients is associated with earlier, more rapidly progressive recurrence or graft and patient survival.

Giampaolo Bianchi, Francesco Nicolino, Giorgia Passerini, Gian Luca Grazi, Paola Zappoli, Romina Graziani, Annalisa Berzigotti, Raffaela Chianese, Vilma Mantovani, Antonio Daniele Pinna, Marco Zoli – 28 December 2005 – Patients submitted to orthotopic liver transplantation (OLT) show an increased rate of cardiovascular events. OLT subjects have high homocysteine (Hcy) levels, but no data are available on the association of Hcy with cardiovascular events. In a cross‐sectional analysis, 230 subjects were studied at least 6 months after OLT (159 on cyclosporine, 71 on tacrolimus).

I. Stelzmueller, M. Biebl, I. Graziadei, S. Wiesmayr, R. Margreiter, H. Bonatti – 28 December 2005