Liver laceration associated with severe seizures after living donor liver transplantation

Kazushige Sato, Satoshi Sekiguchi, Yorihiro Akamatsu, Naoki Kawagishi, Yoshitaka Enomoto, Takeru Iwane, Akira Sato, Keisei Fujimori, Susumu Satomi – 28 December 2005 – Hemorrhagic complications commonly occur early after liver transplantation (LT), sometimes requiring emergent relaparotomy. However, active bleeding from the liver graft itself is a rare but life‐threatening complication after living donor liver transplantation (LDLT).

Histologic characteristics of late cellular rejection, significance of centrilobular injury, and long‐term outcome in pediatric liver transplant recipients

Shikha S. Sundaram, Hector Melin‐Aldana, Katie Neighbors, Estella M. Alonso – 28 December 2005 – Cellular rejection is a common event in orthotopic liver transplantation, leading to significant morbidity and mortality. Late acute cellular rejection, which occurs at least 3 months post‐transplant, affects 8–32% of pediatric liver transplant recipients. The histopathology and clinical outcome of patients affected by late cellular rejection are incompletely understood.

Living donor liver transplantation—Adult donor outcomes: A systematic review

Philippa F. Middleton, Michael Duffield, Stephen V. Lynch, Robert T.A. Padbury, Tony House, Peter Stanton, Deborah Verran, Guy Maddern – 28 December 2005 – The objective of this study was to evaluate the safety and efficacy of adult‐to‐adult living donor liver transplantation, specifically donor outcomes. A systematic review, with searches of the literature up to January 2004, was undertaken. Two hundred and fourteen studies provided information on donor outcomes.

Proposal of a modified Child‐Turcotte‐Pugh scoring system and comparison with the model for end‐stage liver disease for outcome prediction in patients with cirrhosis

Teh‐Ia Huo, Han‐Chieh Lin, Jaw‐Ching Wu, Fa‐Yauh Lee, Ming‐Chih Hou, Pui‐Ching Lee, Full‐Young Chang, Shou‐Dong Lee – 28 December 2005 – The model for end‐stage liver disease (MELD) has a better predictive accuracy for survival than the Child‐Turcotte‐Pugh (CTP) system and has been the primary reference for organ allocation in liver transplantation. The CTP system, with a score range of 5–15, has a ceiling effect that may compromise its predictive power. In this study, we proposed a refined CTP scoring method and investigated its predictive ability.

Balloon dilatation vs. balloon dilatation plus bile duct endoprostheses for treatment of anastomotic biliary strictures after liver transplantation

Thomas Zoepf, Evelyn J. Maldonado‐Lopez, Philip Hilgard, Massimo Malago, Christoph E. Broelsch, Ulrich Treichel, Guido Gerken – 28 December 2005 – Biliary strictures after liver transplantation are a therapeutic challenge for endoscopy. Anastomotic strictures occur in 10% of patients after liver transplantation, leading untreated to mortality and ultimately to graft failure. Despite of successful reports, to date, there is no defined endoscopic therapy regimen for these cases.

Plasma total homocysteine and cardiovascular risk in patients submitted to liver transplantation

Giampaolo Bianchi, Francesco Nicolino, Giorgia Passerini, Gian Luca Grazi, Paola Zappoli, Romina Graziani, Annalisa Berzigotti, Raffaela Chianese, Vilma Mantovani, Antonio Daniele Pinna, Marco Zoli – 28 December 2005 – Patients submitted to orthotopic liver transplantation (OLT) show an increased rate of cardiovascular events. OLT subjects have high homocysteine (Hcy) levels, but no data are available on the association of Hcy with cardiovascular events. In a cross‐sectional analysis, 230 subjects were studied at least 6 months after OLT (159 on cyclosporine, 71 on tacrolimus).

Recurrent hepatitis C posttransplant: Early preservation injury may predict poor outcome

Kymberly D.S. Watt, Elizabeth R. Lyden, James M. Gulizia, Timothy M. McCashland – 28 December 2005 – Organ cold/warm ischemia is thought to be a risk factor for increased severity of recurrence of hepatitis C (HCV) post liver transplantation. We had noted some HCV patients with preservation injury (PI) to have particularly poor outcomes. Our goal was to determine if PI on biopsy in HCV patients is associated with earlier, more rapidly progressive recurrence or graft and patient survival.

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