Ruben Raphael Plentz, Young Nyun Park, André Lechel, Haeryoung Kim, Friederike Nellessen, Britta Heike Eva Langkopf, Ludwig Wilkens, Annarita Destro, Barbara Fiamengo, Michael Peter Manns, Massimo Roncalli, Karl Lenhard Rudolph – 28 March 2007 – Telomere shortening and inactivation of cell cycle checkpoints characterize carcinogenesis. Whether these molecular features coincide at specific stages of human hepatocarcinogenesis is unknown. The preneoplasia–carcinoma sequence of human HCC is not well defined.

Olivier Barbier, Jocelyn Trottier – 28 March 2007

Max Werth, Frank Gaunitz, Rolf Gebhardt – 28 March 2007

Sang Lee, Kathleen M. Gura, Mark Puder – 28 March 2007

Virginie Cerec, Denise Glaise, Delphine Garnier, Serban Morosan, Bruno Turlin, Bernard Drenou, Philippe Gripon, Dina Kremsdorf, Christiane Guguen‐Guillouzo, Anne Corlu – 28 March 2007 – Hepatic tumors, exhibiting mature hepatocytes and undifferentiated cells merging with cholangiocyte and hepatocyte phenotypes, are frequently described. The mechanisms by which they occur remain unclear. We report differentiation and transdifferentiation behaviors of human HepaRG cells isolated from a differentiated tumor developed consecutively to chronic HCV infection.

Paul Angulo, Jason M. Hui, Giulio Marchesini, Ellisabetta Bugianesi, Jacob George, Geoffrey C. Farrell, Felicity Enders, Sushma Saksena, Alastair D. Burt, John P. Bida, Keith Lindor, Schuyler O. Sanderson, Marco Lenzi, Leon A. Adams, James Kench, Terry M. Therneau, Christopher P. Day – 28 March 2007 – Patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis are at the highest risk for progressing to end‐stage liver disease.

Shawn Wasilenko, Andrew L. Mason – 28 March 2007

Shuji Kanmura, Hirofumi Uto, Kazunori Kusumoto, Yoichi Ishida, Satoru Hasuike, Kenji Nagata, Katsuhiro Hayashi, Akio Ido, Sherri Oliver Stuver, Hirohito Tsubouchi – 28 March 2007 – Early detection of HCC increases the potential for curative treatment and improves survival. To facilitate early detection of HCC, this study sought to identify novel diagnostic markers of HCC using surface‐enhanced laser desorption ionization time‐of‐flight mass spectrometry (SELDI‐TOF/MS) ProteinChip technology.

Kazuaki Inoue, Takuya Umehara, Urs T. Ruegg, Fumihiko Yasui, Tsunamasa Watanabe, Hiroshi Yasuda, Jean‐Maurice Dumont, Pietro Scalfaro, Makoto Yoshiba, Michinori Kohara – 28 March 2007 – Cyclosporin A (CsA) inhibits replication of the HCV subgenomic replicon, and this effect is believed to not be mediated by its immunosuppressive action. We found that DEBIO‐025, a novel non‐immunosuppressive cyclophilin inhibitor derived from CsA, inhibited HCV replication in vitro more potently than CsA.

Christoph Schmöcker, Karsten H. Weylandt, Lena Kahlke, Jingdong Wang, Hartmut Lobeck, Gisa Tiegs, Thomas Berg, Jing X. Kang – 28 March 2007 – Cytokines such as tumor necrosis factor alpha (TNF‐α) are key factors in liver inflammation. Supplementation with essential omega‐3 polyunsaturated fatty acids (n‐3 PUFA) has been demonstrated to lower TNF‐α and IL‐1 production in mononuclear cells. An inflammation‐dampening effect has been observed with increased omega‐3 fatty acid supplementation in several inflammatory diseases.