Parenteral nutrition–associated liver disease and the role for isolated intestine and intestine/liver transplantation

Alan L. Buchman, Kishore Iyer, Jonathan Fryer – 22 December 2005 – Parenteral nutrition–associated liver disease (PNALD) is the most devastating complication of long‐term parenteral nutrition therapy. Because its progression is typically insidious and its long‐term consequences are generally underappreciated, PNALD is often recognized too late, when liver injury is irreversible.

Systemic hemodynamics, vasoactive systems, and plasma volume in patients with severe Budd‐Chiari syndrome

Manuel Hernández‐Guerra, Eric López, Pablo Bellot, Carlos Piera, Juan Turnes, Juan G. Abraldes, Jaime Bosch, Juan C. García‐Pagán – 22 December 2005 – Budd‐Chiari syndrome (BCS) causes postsinusoidal portal hypertension, which leads to complications similar to those observed in cirrhosis. However, no studies have investigated whether patients with BCS develop the hyperdynamic circulatory syndrome present in patients with cirrhosis who have portal hypertension.

Limitation of combination therapy of interferon and ribavirin for older patients with chronic hepatitis C

Yoshiaki Iwasaki, Hiroshi Ikeda, Yasuyuki Araki, Toshiya Osawa, Keiji Kita, Masaharu Ando, Toshinari Shimoe, Kouichi Takaguchi, Noriaki Hashimoto, Toshitsugu Kobatake, Minoru Tomita, Mitsuhiko Kawaguchi, Haruhiko Kobashi, Kohsaku Sakaguchi, Yasushi Shiratori – 22 December 2005 – In contrast to the United States, Japanese patients with chronic hepatitis C currently treated with interferon are generally 10 to 15 years older. Older patients, however, tend to experience more frequent adverse events.

Development and validation of two models for early prediction of response to therapy in genotype 1 chronic hepatitis C

Eva Martínez‐Bauer, Javier Crespo, Manuel Romero‐Gómez, Ricardo Moreno‐Otero, Ricard Solá, Nancy Tesei, Fernando Pons, Xavier Forns, José M. Sánchez‐Tapias – 22 December 2005 – Early prediction of response to therapy in genotype 1 chronic hepatitis C is difficult. Two predictive models, a pretreatment scoring model (PreT‐SM) and a fourth week of therapy scoring model (4w‐SM) were constructed in a cohort of 104 patients from a single center (estimation cohort) and validated in a cohort of 141 patients from four independent centers (validation cohort).

Subscribe to