Hepatic artery thrombosis following orthotopic liver transplantation: A 10‐year experience from a single centre in the United Kingdom

Michael A. Silva, Periyathambi S. Jambulingam, Bridget K. Gunson, David Mayer, John A.C. Buckels, Darius F. Mirza, Simon R. Bramhall – 28 December 2005 – Hepatic artery thrombosis (HAT) occurs in 3–9% of all liver transplants and acute graft loss is a possible sequelae. We present our experience in the management of HAT over a 10‐year period. Prospectively collected data from April 1994 to April 2004 were analyzed. There were 1,257 liver transplants, 669 males, median age 51 (16–73) years. There were 61 (4.9%) cases of HAT. Early HAT occurred in 21 (1.8%).

Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing

Claire Terry, Anil Dhawan, Ragai R. Mitry, Sharon C. Lehec, Robin D. Hughes – 28 December 2005 – Cryopreservation of human hepatocytes is important for the treatment of liver disease by hepatocyte transplantation and also for the use of hepatocytes as an in vitro model of the liver. One factor in the success of cryopreservation is the quality of cells before freezing.

Coccidioidomycosis in liver transplantation

Janis E. Blair – 28 December 2005 – Coccidioidomycosis is an endemic fungal infection in the southwestern United States. It causes morbidity and mortality among solid organ transplant recipients who reside in or visit the endemic area or who receive organs from donors infected with the fungus. This paper reviews current literature addressing these infections in liver transplantation programs, including risk factors, clinical manifestations in persons with cirrhosis or who have had a liver transplantation, prophylaxis, treatment, and outcomes. Liver Transpl 12:31–39, 2006. © 2005 AASLD.

Liver laceration associated with severe seizures after living donor liver transplantation

Kazushige Sato, Satoshi Sekiguchi, Yorihiro Akamatsu, Naoki Kawagishi, Yoshitaka Enomoto, Takeru Iwane, Akira Sato, Keisei Fujimori, Susumu Satomi – 28 December 2005 – Hemorrhagic complications commonly occur early after liver transplantation (LT), sometimes requiring emergent relaparotomy. However, active bleeding from the liver graft itself is a rare but life‐threatening complication after living donor liver transplantation (LDLT).

Histologic characteristics of late cellular rejection, significance of centrilobular injury, and long‐term outcome in pediatric liver transplant recipients

Shikha S. Sundaram, Hector Melin‐Aldana, Katie Neighbors, Estella M. Alonso – 28 December 2005 – Cellular rejection is a common event in orthotopic liver transplantation, leading to significant morbidity and mortality. Late acute cellular rejection, which occurs at least 3 months post‐transplant, affects 8–32% of pediatric liver transplant recipients. The histopathology and clinical outcome of patients affected by late cellular rejection are incompletely understood.

Living donor liver transplantation—Adult donor outcomes: A systematic review

Philippa F. Middleton, Michael Duffield, Stephen V. Lynch, Robert T.A. Padbury, Tony House, Peter Stanton, Deborah Verran, Guy Maddern – 28 December 2005 – The objective of this study was to evaluate the safety and efficacy of adult‐to‐adult living donor liver transplantation, specifically donor outcomes. A systematic review, with searches of the literature up to January 2004, was undertaken. Two hundred and fourteen studies provided information on donor outcomes.

Proposal of a modified Child‐Turcotte‐Pugh scoring system and comparison with the model for end‐stage liver disease for outcome prediction in patients with cirrhosis

Teh‐Ia Huo, Han‐Chieh Lin, Jaw‐Ching Wu, Fa‐Yauh Lee, Ming‐Chih Hou, Pui‐Ching Lee, Full‐Young Chang, Shou‐Dong Lee – 28 December 2005 – The model for end‐stage liver disease (MELD) has a better predictive accuracy for survival than the Child‐Turcotte‐Pugh (CTP) system and has been the primary reference for organ allocation in liver transplantation. The CTP system, with a score range of 5–15, has a ceiling effect that may compromise its predictive power. In this study, we proposed a refined CTP scoring method and investigated its predictive ability.

Balloon dilatation vs. balloon dilatation plus bile duct endoprostheses for treatment of anastomotic biliary strictures after liver transplantation

Thomas Zoepf, Evelyn J. Maldonado‐Lopez, Philip Hilgard, Massimo Malago, Christoph E. Broelsch, Ulrich Treichel, Guido Gerken – 28 December 2005 – Biliary strictures after liver transplantation are a therapeutic challenge for endoscopy. Anastomotic strictures occur in 10% of patients after liver transplantation, leading untreated to mortality and ultimately to graft failure. Despite of successful reports, to date, there is no defined endoscopic therapy regimen for these cases.

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