Impact of UCSF criteria according to pre‐ and post‐OLT tumor features: Analysis of 479 patients listed for HCC with a short waiting time

Thomas Decaens, Françoise Roudot‐Thoraval, Solange Hadni‐Bresson, Carole Meyer, Jean Gugenheim, Francois Durand, Pierre‐Henri Bernard, Olivier Boillot, Laurent Sulpice, Yvon Calmus, Jean Hardwigsen, Christian Ducerf, Georges‐Philippe Pageaux, Sebastien Dharancy, Olivier Chazouilleres, Daniel Cherqui, Christophe Duvoux – 8 September 2006 – Orthotopic liver transplantation (OLT) indication for hepatocellular carcinoma (HCC) is currently based on the Milan criteria.

The role of 18F‐FDG‐PET imaging for the selection of liver transplantation candidates among hepatocellular carcinoma patients

Sung Hoon Yang, Kyung‐Suk Suh, Hae Won Lee, Eung‐Ho Cho, Jai Young Cho, Yong Beom Cho, Nam‐Joon Yi, Kuhn Uk Lee – 8 September 2006 – Positron emission tomography (PET) using F‐18 fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is now well established as a noninvasive diagnostic tool for the detection of a variety of malignant tumors. However, in the case of hepatocellular carcinoma (HCC), several investigators have reported controversial conclusions and an inadequate sensitivity for PET (50‐55%).

Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation

Stuart A. McCluskey, Keyvan Karkouti, Duminda N. Wijeysundera, Karen Kakizawa, Mohammed Ghannam, Ahmed Hamdy, David Grant, Gary Levy – 1 September 2006 – Massive blood transfusion (MBT) remains a serious and common occurrence in liver transplantation surgery. This retrospective cohort study was undertaken to identify preoperative predictors of MBT and to develop a risk index for MBT in liver transplantation. Data were retrospectively collected on all liver transplantations carried out at a single institution between January 1998 and March 2004.

Accuracy of magnetic resonance imaging for preoperative detection of portal vein thrombosis in liver transplant candidates

Tilak U. Shah, Richard C. Semelka, Vasilis Voultsinos, Jorge Elias Jr., Ersan Altun, Ertan Pamuklar, Zeynep Firat, David A. Gerber, Jeffrey Fair, Mark W. Russo – 1 September 2006 – The detection of main portal vein thrombosis (PVT) on preoperative imaging of liver transplant candidates has important technical implications for the transplantation procedure. Data are scarce regarding the accuracy of magnetic resonance imaging (MRI) at detecting PVT. The aim of our study was to compare preoperative findings of the portal vein on MRI to operative findings at liver transplantation.

Development and validation of a model predicting graft survival after liver transplantation

George N. Ioannou – 1 September 2006 – This study aimed to develop and validate a comprehensive model that predicts survival after liver transplantation based on pretransplant donor and recipient characteristics. Complete data were available from the United Network for Organ Sharing for 20,301 persons who underwent liver transplantation in the United States between 1994 and 2003. Proportional‐hazards regression was used to identify the donor and recipient characteristics that best predicted survival and incorporate these characteristics in a multivariate model.

Incidence and risk factors for the development of prolonged and severe intrahepatic cholestasis after liver transplantation

Giuseppe Fusai, Parveen Dhaliwal, Nancy Rolando, Caroline Anne Sabin, David Patch, Brian Ritchie Davidson, Andrew Kenneth Burroughs, Keith Rolles – 1 September 2006 – Predictive factors for intrahepatic cholestasis after orthotopic liver transplantation (OLT) have not yet been established. We sought to identify the incidence and risk factors associated with prolonged severe intrahepatic cholestasis (PSIC) after OLT. We assessed 428 consecutive patients undergoing their first OLT.

pH‐independent entry and sequential endosomal sorting are major determinants of hepadnaviral infection in primary hepatocytes

Anneke Funk, Mouna Mhamdi, Heinz Hohenberg, Hans Will, Hueseyin Sirma – 29 August 2006 – Entry and intracellular transport of hepatitis B viruses have several unusual, largely unknown aspects. In this study, we explored the mode of virus entry using the duck hepatitis B virus (DHBV) and the primary hepatocyte infection model. Upon internalization, viral particles were enriched in an endosomal compartment, as revealed by biochemical and ultrastructural analysis. Virus‐containing vesicles harbored early endosome markers.

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