Liver laceration associated with severe seizures after living donor liver transplantation

Kazushige Sato, Satoshi Sekiguchi, Yorihiro Akamatsu, Naoki Kawagishi, Yoshitaka Enomoto, Takeru Iwane, Akira Sato, Keisei Fujimori, Susumu Satomi – 28 December 2005 – Hemorrhagic complications commonly occur early after liver transplantation (LT), sometimes requiring emergent relaparotomy. However, active bleeding from the liver graft itself is a rare but life‐threatening complication after living donor liver transplantation (LDLT).

Coccidioidomycosis in liver transplantation

Janis E. Blair – 28 December 2005 – Coccidioidomycosis is an endemic fungal infection in the southwestern United States. It causes morbidity and mortality among solid organ transplant recipients who reside in or visit the endemic area or who receive organs from donors infected with the fungus. This paper reviews current literature addressing these infections in liver transplantation programs, including risk factors, clinical manifestations in persons with cirrhosis or who have had a liver transplantation, prophylaxis, treatment, and outcomes. Liver Transpl 12:31–39, 2006. © 2005 AASLD.

Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing

Claire Terry, Anil Dhawan, Ragai R. Mitry, Sharon C. Lehec, Robin D. Hughes – 28 December 2005 – Cryopreservation of human hepatocytes is important for the treatment of liver disease by hepatocyte transplantation and also for the use of hepatocytes as an in vitro model of the liver. One factor in the success of cryopreservation is the quality of cells before freezing.

Hepatic artery thrombosis following orthotopic liver transplantation: A 10‐year experience from a single centre in the United Kingdom

Michael A. Silva, Periyathambi S. Jambulingam, Bridget K. Gunson, David Mayer, John A.C. Buckels, Darius F. Mirza, Simon R. Bramhall – 28 December 2005 – Hepatic artery thrombosis (HAT) occurs in 3–9% of all liver transplants and acute graft loss is a possible sequelae. We present our experience in the management of HAT over a 10‐year period. Prospectively collected data from April 1994 to April 2004 were analyzed. There were 1,257 liver transplants, 669 males, median age 51 (16–73) years. There were 61 (4.9%) cases of HAT. Early HAT occurred in 21 (1.8%).

National and regional analysis of exceptions to the pediatric end‐stage liver disease scoring system (2003–2004)

Benjamin L. Shneider, Frederick J. Suchy, Sukru Emre – 28 December 2005 – Since February 2002, the Pediatric End Stage Liver Disease (PELD) scoring system has been utilized as a means of prioritizing children for liver transplantation. The United Network for Organ Sharing database was queried to assess utilization of PELD in 2003 and 2004; 682 liver transplants were performed in pediatric recipients where the PELD score was potentially the primary determinant of liver allocation.

Validity of the Spanish version of the Chronic Liver Disease Questionnaire (CLDQ) as a standard outcome for quality of life assessment

Montserrat Ferrer, Juan Córdoba, Olatz Garin, Gemma Olivé, Montserrat Flavià, Victor Vargas, Rafael Esteban, Jordi Alonso – 28 December 2005 – The Chronic Liver Disease Questionnaire (CLDQ) measures the impact on quality of life of chronic liver diseases, regardless of underlying etiology. The aim of this study was to develop a Spanish version of the CLDQ, and to assess its acceptability, reliability, validity, and sensitivity to change. The forward and back‐translation method by bilingual translators, with expert panel and pilot testing on patients, was used for the adaptation.

Efficacy and safety of low‐dose valganciclovir in the prevention of cytomegalovirus disease in adult liver transplant recipients

Jeong M. Park, Kathleen D. Lake, Juan D. Arenas, Robert J. Fontana – 28 December 2005 – The efficacy and safety of valganciclovir (VGCV) for cytomegalovirus (CMV) prophylaxis in liver transplant recipients has not been established. We retrospectively compared the efficacy and safety of low‐dose oral VGCV (450 mg once daily for 90 days) and standard oral ganciclovir (1 g three times a day for 90 days, GCV) in preventing CMV disease in 109 adult liver transplant recipients who survived at least 1 month between January 2001 and April 2003 (49 GCV and 60 VGCV).

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