Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C

Carolin Lackner, Gerd Struber, Bernadette Liegl, Sebastian Leibl, Petra Ofner, Csilla Bankuti, Bernd Bauer, Rudolf E. Stauber – 24 May 2005 – Liver biopsy is recommended before antiviral treatment, particularly for patients with hepatitis C virus (HCV) genotype 1 infection, but it may cause complications and is limited by sampling error. Several non‐invasive tests comprising routine laboratory parameters (simple fibrosis tests) have been proposed to predict fibrosis in chronic HCV.

Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma model

Esther Raskopf, Christian Dzienisowicz, Tobias Hilbert, Christian Rabe, Ludger Leifeld, Nicolas Wernert, Tilman Sauerbruch, Jesús Prieto, Cheng Qian, Wolfgang H. Caselmann, Volker Schmitz – 24 May 2005 – Vascular endothelial growth factor (VEGF) activity is correlated with a progressive tumor disease in patients with hepatocellular carcinoma (HCC). In spite of the well‐recognized role of VEGF in HCC, there are few data available regarding therapeutic strategies to block VEGF activity.

Cryopreserved iliac artery is indispensable interposition graft material for middle hepatic vein reconstruction of right liver grafts

Shin Hwang, Sung‐Gyu Lee, Chul‐Soo Ahn, Kwang‐Min Park, Ki‐Hun Kim, Deok‐Bog Moon, Tae‐Yong Ha – 24 May 2005 – Cryopreserved iliac vein grafts (IVGs) have often been used for reconstruction of middle hepatic vein (MHV) branches in right liver grafts, but their storage pool has often been exhausted in our institution due to the low incidence of deceased donor organ procurement. To overcome this shortage of IVG, we started to use cryopreserved iliac artery graft (IAG).

Transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a non‐heart beating donor

Olivier Detry, Arnaud De Roover, Laurence de Leval, Christian Herens, Jean Delwaide, Pierre Honoré, Michel Meurisse – 24 May 2005 – Transmission of an undiagnosed cancer with solid organ transplantation is a rare but dreadful event. In this paper the authors report the transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a Maastricht category 3 non‐heart beating donor. To the authors' knowledge this case is the first report of such a transmission with a liver graft procured in a non‐heart beating donor.

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