Tohru Adachi, Hitoshi Togashi, Akihiko Suzuki, Shigenobu Kasai, Junitsu Ito, Kazuhiko Sugahara, Sumio Kawata – 24 May 2005 – The proliferation of hepatic stellate cells (HSCs) is a critical step in hepatic fibrogenesis. Platelet‐derived growth factor (PDGF) is the most potent mitogen for HSCs. We investigated the role of nonphagocytic NAD(P)H oxidase–derived reactive oxygen species (ROS) in PDGF‐induced HSC proliferation. The human HSC line, LI‐90 cells, murine primary‐cultured HSCs, and PDGF‐BB were used in this study.

Walter C. Hellinger, Hugo Bonatti, Joseph D. Yao, Salvador Alvarez, Lisa M. Brumble, Michael R. Keating, Julio C. Mendez, David J. Kramer, Rolland C. Dickson, Denise M. Harnois, James R. Spivey, Christopher B. Hughes, Justin H. Nguyen, Jeffery L. Steers – 24 May 2005 – Antifungal prophylaxis has been proposed for liver transplant recipients at increased risk for invasive mold infection.

Christopher D. Anderson, Janene Pierce, Ian Nicoud, Andrey Belous, Clayton D. Knox, Ravi S. Chari – 24 May 2005 – Hepatic warm ischemia and reperfusion (IR) injury occurs in many clinical situations and has an important link to subsequent hepatic failure. The pathogenesis of this injury involves numerous pathways, including mitochondrial‐associated apoptosis. We studied the effect of mitochondrial calcium uptake inhibition on hepatic IR injury using the specific mitochondrial calcium uptake inhibitor, ruthenium red (RR).

Jacek B. Cywinski, Maged Argalious, Theodore N. Marks, Brian M. Parker – 24 May 2005 – A 53 year‐old man with Laennec's and hepatitis C–related cirrhosis was found to have dynamic left ventricular outflow tract obstruction during routine evaluation for orthotopic liver transplantation. The outflow tract obstruction gradient was quantified as being 155 to 189 mmHg maximally during dobutamine stress echocardiography. The patient subsequently underwent successful orthotopic liver transplantation at our institution.

Marie‐Noëlle Brunelle, Anne‐Carole Jacquard, Christian Pichoud, David Durantel, Sandra Carrouée‐Durantel, Jean‐Pierre Villeneuve, Christian Trépo, Fabien Zoulim – 24 May 2005 – Mutations within the hepatitis B virus (HBV) polymerase gene conferring drug‐resistance are selected during prolonged lamivudine (3TC) or adefovir dipivoxil (ADV) treatment. Because there is no other approved drug against HBV, treatments with 3TC or ADV are used either sequentially or in addition, depending on treatment response or failure.

Adrian Reuben – 24 May 2005

Nina Singh, Cheryl Wannstedt, Lois Keyes, Marilyn M. Wagener, Thomas V. Cacciarelli – 24 May 2005 – A vast majority of the transplant recipients are cytomegalovirus (CMV)‐seropositive (R+). We sought to assess variables predictive of CMV infection, specifically in R+ liver transplant recipients. Study patients comprised 182 consecutive liver transplant recipients who survived at least 14 days after transplantation. Surveillance testing was used to detect CMV infection.

Yunfang Wang, Xue Nan, Yanhua Li, Rui Zhang, Wen Yue, Fang Yan, Xuetao Pei – 24 May 2005 – Several studies have indicated that adult stem cells derived from bone marrow (BM) and cord blood (CB) can differentiate into hepatocyte‐like cells. This ability is important for the treatment of hepatic diseases with BM or CB as a potential approach. However, methods are still being developed for the efficient induction of stem cell differentiation and expansion to get enough cells to be useful.

24 May 2005

Eveline Boucher, Harvey J. Turner, Patrick Bourguet, Jean‐Luc Raoul – 24 May 2005