Jeremy J. Theal, Mohssen N. Toosi, Larisa Girlan, Ronald J. Heslegrave, Pierre‐Michel Huet, Kelly W. Burak, Mark Swain, George A. Tomlinson, E. Jenny Heathcote – 24 May 2005 – Fatigue is common in primary biliary cirrhosis (PBC). Altered central serotonergic neurotransmission may be involved in its pathogenesis. This multicenter, randomized, double‐blind, placebo‐controlled, crossover trial evaluated the efficacy of ondansetron, a selective 5‐HT3 receptor subtype antagonist, for treating fatigue in PBC.

Jasmohan Singh Bajaj, Ashwin Ananthakrishnan, Kia Saeian – 24 May 2005

J. Michael Henderson – 24 May 2005

Henry Lik‐Yuen Chan, Alex Yui Hui, Vincent Wai‐Sun Wong, Angel Mei‐Ling Chim, May‐Ling Wong, Joseph Jao‐Yiu Sung – 23 May 2005 – We have previously demonstrated that combination peginterferon and lamivudine treatment has superior antiviral efficacy to lamivudine monotherapy in chronic hepatitis B. In this study, we investigated the long‐term posttreatment virological response to this combination treatment.

Frank Gaunitz, Danilo Deichsel, Kerstin Heise, Max Werth, Ulf Anderegg, Rolf Gebhardt – 23 May 2005 – The most striking phenomenon of glutamine synthetase (GS) expression in the liver is its unique restriction to cells surrounding the terminal hepatic venules. Expression is positively regulated by elements located in the 5′‐upstream region and in the first intron of the gene. It was long believed that transcription factors present in GS‐positive cells and absent in GS‐negative cells are responsible for the phenomenon of zonal expression.

LiFu Wang, Anne‐Christine Piguet, Karin Schmidt, Thierry Tordjmann, Jean‐François Dufour – 23 May 2005 – Tauroursodeoxycholic acid (TUDCA) is a cytoprotective bile acid frequently prescribed to patients with cholestatic diseases. Several mechanisms of action have been investigated, but the possibility that cyclic adenosine monophosphate responsive element binding protein (CREB), a transcription factor promoting cell survival, mediates TUDCA's protective effects has not been considered.

Alexander V. Kofman, Glyn Morgan, Adam Kirschenbaum, Jon Osbeck, Mehboob Hussain, Scott Swenson, Neil D. Theise – 23 May 2005 – We examined the response of murine oval cells, that is, the putative liver progenitor cells, to acetaminophen. Female C57BL/6J mice were injected intraperitoneally with varying doses of N‐acetyl‐paraaminophen (APAP) (250, 500, 750, and 1,000 mg/kg of weight) and sacrificed at 3, 6, 9, 24, and 48 hours. In preliminary studies, we showed that anticytokeratin antibodies detected A6‐positive cells with a sensitivity and specificity of greater than 99%.

Carlo Alessandria, Osman Ozdogan, Mónica Guevara, Tea Restuccia, Wladimiro Jiménez, Vicente Arroyo, Juan Rodés, Pere Ginès – 23 May 2005 – Important progress has been made recently regarding the pathogenesis and treatment of hepatorenal syndrome (HRS). However, scant information exists about factors predicting outcome in patients with cirrhosis and HRS. Moreover, the prognostic value of the model of end‐stage liver disease (MELD) score has not been validated in the setting of HRS.

John G. Lunz, Hirokazu Tsuji, Isao Nozaki, Noriko Murase, Anthony J. Demetris – 23 May 2005 – During the evolution of cirrhosis, there is a relative decrease in volume percentage of hepatocytes and a relative increase in biliary epithelial cells and myofibroblasts. This is recognized histopathologically as a ductular reaction and leads to gradual distortion of the normal hepatic architecture.

Kazutaka Obama, Katsuaki Ura, Meihua Li, Toyomasa Katagiri, Tatsuhiko Tsunoda, Akinari Nomura, Seiji Satoh, Yusuke Nakamura, Yoichi Furukawa – 23 May 2005 – Intrahepatic cholangiocarcinoma is a neoplasm arising in the liver, and its incidence is increasing in Japan as well as in Western countries. Prognosis of patients with this type of tumor remains unsatisfactory because no effective chemotherapeutic drugs are available, we have no sensitive tumor markers to detect this tumor in its early stage, and it is difficult to identify a high‐risk group for the disease.