Christine L. Powell, Oksana Kosyk, Blair U. Bradford, Joel S. Parker, Edward K. Lobenhofer, Ayumi Denda, Fumiyuki Uematsu, Dai Nakae, Ivan Rusyn – 25 October 2005 – Hepatocellular carcinoma (HCC) is the terminal event in chronic liver diseases with repeated cycles of cellular injury and regeneration. Although much is known about the cellular pathogenesis and etiological agents leading to HCC, the molecular events are not well understood.

Jordan Feld, E. Jenny Heathcote – 25 October 2005

Jordi Bruix, Morris Sherman – 25 October 2005

Amedeo Columbano, Giovanna M. Ledda‐Columbano, Monica Pibiri, Costanza Cossu, Marta Menegazzi, David D. Moore, Wendong Huang, Jianmin Tian, Joseph Locker – 25 October 2005 – We previously observed that Gadd45β/MyD118, a member of the Gadd45 family of inducible factors, showed the strongest immediate‐early induction common to two distinctive proliferation responses of the liver: (1) regeneration induced by surgical partial hepatectomy and (2) hyperplasia induced by the primary mitogen TCPOBOP, a ligand of the constitutive androstane receptor (CAR).

Burton Combes, Scott S. Emerson, Nancy L. Flye, Santiago J. Munoz, Velimir A. Luketic, Marlyn J. Mayo, Timothy M. McCashland, Rowen K. Zetterman, Marion G. Peters, Adrian M. Di Bisceglie, Kent G. Benner, Kris V. Kowdley, Robert L. Carithers, Leonard Rosoff, Guadalupe Garcia‐Tsao, James L. Boyer, Thomas D. Boyer, Enrique J. Martinez, Nathan M. Bass, John R. Lake, David S. Barnes, Maurizio Bonacini, Karen L. Lindsay, A. Scott Mills, Rodney S. Markin, Raphael Rubin, A. Brian West, Donald E. Wheeler, Melissa J. Contos, Alan F.

Torsten Wuestefeld, Christian Klein, Konrad L. Streetz, Naiara Beraza, Jürgen Schölmerich, Lawrence J. Burgart, Lars Zender, Stefan Kubicka, Gregory J. Gores, Michael P. Manns, Christian Trautwein – 25 October 2005 – Chronic cholestasis is associated with increased bacterial infections and sepsis resulting in higher mortality in humans. In the current study, we investigated the relevance of gp130‐dependent pathways after bile duct ligation (BDL). BDL was performed in conditional gp130 knockout (loxP/Cre system) mice and respective controls.

Elisabetta Bugianesi, Arthur J. McCullough, Giulio Marchesini – 25 October 2005 – Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty liver disease (NAFLD), one of the most common causes of chronic liver disease in Western countries. We review the definition of IR, the methods for the quantitative assessment of insulin action, the pathophysiology of IR, and the role of IR in the pathogenesis of chronic liver disease.

Patrick Bertolino, Arnhild Schrage, David G. Bowen, Katja Klugewitz, Saeed Ghani, Katharina Eulenburg, Lauren Holz, Nancy Hogg, Geoffrey W. McCaughan, Alf Hamann – 25 October 2005 – We have previously shown that naïve CD8+ T cells recognizing their cognate antigen within the liver are retained and undergo activation in situ, independent from lymphoid tissues. Intrahepatic primary T cell activation results in apoptosis and may play a crucial role in the ability of the liver to induce tolerance.

Daniel Benten, Vinay Kumaran, Brigid Joseph, Jörn Schattenberg, Yury Popov, Detlef Schuppan, Sanjeev Gupta – 25 October 2005 – We investigated whether transplanted hepatocytes interact with hepatic stellate cells, as cell–cell interactions could modulate their engraftment in the liver. We transplanted Fischer 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV–deficient rats.

Darren J. Schofield, Birke Bartosch, Yohko K. Shimizu, Tobias Allander, Harvey J. Alter, Suzanne U. Emerson, François‐Loïc Cosset, Robert H. Purcell – 25 October 2005 – Active and/or passive immunoprophylaxis against hepatitis C virus (HCV) remain unachieved goals. Monoclonal antibodies might provide one approach to protection. We derived human monoclonal antibodies from the bone marrow of a patient with a well‐controlled HCV infection of 22 years duration.