Machine perfusion in liver transplantation

Richard X. Sousa Da Silva, Achim Weber, Philipp Dutkowski, Pierre‐Alain Clavien – 29 April 2022 – Although liver transplantation is a true success story, many patients still die awaiting an organ. The increasing need for liver grafts therefore remains an unsolved challenge to the transplant community. To address this, transplant donor criteria have been expanded and, for example, more liver grafts with significant steatosis or from donors with circulatory death are being used.

A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis

Akiko Eguchi, Motoh Iwasa, Minori Yamada, Yasuyuki Tamai, Ryuta Shigefuku, Hiroshi Hasegawa, Yoshifumi Hirokawa, Akinobu Hayashi, Koji Okuno, Yuki Matsushita, Takuma Nakatsuka, Kenichiro Enooku, Koji Sakaguchi, Yoshinao Kobayashi, Tetsuji Yamaguchi, Masatoshi Watanabe, Yoshiyuki Takei, Hayato Nakagawa – 28 April 2022 – Caspase‐generated fragmented cytokeratin 18 (fCK18) is recognized as a useful noninvasive biomarker in the diagnosis of nonalcoholic fatty liver disease (NAFLD), particularly nonalcoholic steatohepatitis (NASH).

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