Hepatic encephalopathy (HE) is a frequent complication and one of the most debilitating manifestations of liver disease, severely affecting the lives of patients and their caregivers.

Hereditary hemochromatosis (HH) remains the most common, identified, genetic disorder in Caucasians.

Disha Sharma, Gil Ben Yakov, Devika Kapuria, Gracia Viana Rodriguez, Meital Gewirtz, James Haddad, David E. Kleiner, Christopher Koh, Jenna R. E. Bergerson, Alexandra F. Freeman, Theo Heller – 24 April 2022 – Inborn errors of immunity (IEIs) consist of numerous rare, inherited defects of the immune system that affect about 500,000 people in the United States. As advancements in diagnosis through genetic testing and treatment with targeted immunotherapy and bone marrow transplant emerge, increasing numbers of patients survive into adulthood posing fresh clinical challenges.

Michael Schonfeld, Janice Averilla, Sumedha Gunewardena, Steven A. Weinman, Irina Tikhanovich – 24 April 2022 – Alcohol‐associated liver disease is a major cause of alcohol‐related mortality. However, the mechanisms underlying disease progression are not fully understood. Recently we found that liver molecular pathways are altered by alcohol consumption differently in males and females. We were able to associate these sex‐specific pathways with two upstream regulators: H3K4‐specific demethylase enzymes KDM5B and KDM5C.

Sarah Wang, Ana Teresa Limon‐Miro, Christofer Cruz, Puneeta Tandon – 23 April 2022

Sarah Wang, Ana Teresa Limon‐Miro, Christofer Cruz, Puneeta Tandon – 23 April 2022

23 April 2022

Aparna Goel, Allison Kwong – 23 April 2022

Aparna Goel, Allison Kwong – 23 April 2022

Alcohol-associated liver disease (ALD) represents a spectrum of liver injury resulting from alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic hepatitis (AH), alcohol-associated cirrhosis (AC), and acute AH presenting as acute-on-chronic liver failure.