NAFLD‐related hepatocellular carcinoma: The growing challenge

Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison – 27 April 2022 – Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially. Genetic predisposition and clinical risk factors for NAFLD‐related HCC have been identified. Cirrhosis is a well‐known and major risk factor for NAFLD‐related HCC.

Serum Mac‐2 binding protein level predicts the development of liver‐related events and colorectal cancer in patients with NAFLD

Yoshihiro Kamada, Takashi Nakahara, Kensuke Munekage, Hideki Fujii, Yoshiyuki Sawai, Yoshinori Doi, Masafumi Ono, Hideyuki Hyogo, Yoshio Sumida, Koichi Morishita, Tatsuya Asuka, Tsunenori Ouchida, Yasuharu Imai, Eiji Miyoshi, Japan Study Group of NAFLD – 26 April 2022 – We previously demonstrated that Mac‐2 binding protein (M2BP) is a useful biomarker for nonalcoholic fatty liver disease (NAFLD), particularly NAFLD fibrosis prediction. In the present study, we investigated the prognostic value of M2BP in patients with NAFLD.

Impact of the new definition of metabolic dysfunction–associated fatty liver disease on detection of significant liver fibrosis in US adolescents

Stefano Ciardullo, Marco Carbone, Pietro Invernizzi, Gianluca Perseghin – 25 April 2022 – Recently, an expert panel proposed diagnostic criteria for metabolic dysfunction–associated fatty liver disease (MAFLD) in the pediatric population. The aim of this study was to evaluate the prevalence of MAFLD among US adolescents and to investigate whether the new MAFLD definition is able to identify individuals with more advanced liver disease.

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