Interaction of metabolic dysfunction‐associated fatty liver disease and nonalcoholic fatty liver disease with advanced fibrosis in the death and intubation of patients hospitalized with coronavirus disease 2019

Martín Uriel Vázquez‐Medina, Eira Cerda‐Reyes, Alberto Galeana‐Pavón, Carlos Enrique López‐Luna, Patty Marlen Ramírez‐Portillo, Gabriela Ibañez‐Cervantes, Julián Torres‐Vázquez, Cruz Vargas‐De‐León – 18 April 2022 – Patients with pre‐existing liver diseases are considered to have an increased risk of morbidity and mortality from any type of infection, including viruses.

Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target

Vaibhav Singh, Emily Huang, Vai Pathak, Belinda B. Willard, Daniela S. Allende, Laura E. Nagy – 18 April 2022 – Receptor‐interaction protein kinase 3 (RIP3), a critical determinant of the necroptotic pathway of programmed cell death, contributes to injury in murine models of alcohol‐associated liver disease (ALD); however, the underlying mechanisms are unknown. We investigated the effect of chronic ethanol feeding on the hepatic phosphoproteome in C57BL/6 and RIP3‐deficient (Rip3−/−) mice, focusing on death receptor (DR) signaling pathways.

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