Standardizing the histological assessment of late posttransplantation biopsies from pediatric liver allograft recipients

Stefan G. Hübscher, Sandy Feng, Annette S. H. Gouw, Hironori Haga, Hyo Jeong Kang, Deirdre A. Kelly, Mina Komuta, Andrew Lesniak, Benjamin A. Popp, Henkjan J. Verkade, Eunsil Yu, Anthony J. Demetris – 15 April 2022 – Excellent short‐term survival after pediatric liver transplantation (LT) has shifted attention toward the optimization of long‐term outcomes. Despite considerable progress in imaging and other noninvasive modalities, liver biopsies continue to be required to monitor allograft health and to titrate immunosuppression.

Proteomics‐based identification of the role of osteosarcoma amplified‐9 in hepatocellular carcinoma recurrence

Xuyong Wei, Mengfan Yang, Binhua Pan, Xiaobing Zhang, Hanchao Lin, Wangyao Li, Wenzhi Shu, Kun Wang, Abdul Rehman Khan, Xuanyu Zhang, Beini Cen, Xiao Xu – 15 April 2022 – Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies; its recurrence is associated with high mortality and poor recurrence‐free survival and is affected by multisystem and multilevel pathological changes.

Elevated fractional donor‐derived cell‐free DNA during subclinical graft injury after liver transplantation

Anna K. Baumann, Julia Beck, Theresa Kirchner, Björn Hartleben, Ekkehard Schütz, Michael Oellerich, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert – 15 April 2022 – Personalized immunosuppression (IS) promises to improve the balance of necessary control of alloreactivity and dose‐dependent adverse effects of long‐term IS such as kidney insufficiency, infections, and malignancies.

Distinct responsiveness to rifaximin in patients with hepatic encephalopathy depends on functional gut microbial species

Yoshimi Yukawa‐Muto, Tomonori Kamiya, Hideki Fujii, Hiroshi Mori, Atsushi Toyoda, Ikuya Sato, Yusuke Konishi, Akiyoshi Hirayama, Eiji Hara, Shinji Fukuda, Norifumi Kawada, Naoko Ohtani – 15 April 2022 – Hepatic encephalopathy (HE) is the neuropsychiatric complication of liver cirrhosis (LC). The influence of gut microbiota on HE pathogenesis has been suggested but not precisely elucidated. Here, we investigate how the gut microbial profile changed in patients with HE to clarify the functional gut microbial species associated with HE.

Tripartite motif‐containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen‐activated protein kinase kinase kinase 7

Min‐Xuan Xu, Jun Tan, Chen‐Xu Ge, Wei Dong, Li‐Ting Zhang, Lian‐Cai Zhu, Jun‐Jie Zhao, Long‐Yan Wang, Jin Liu, Hao Wei, Yan Sun, Xian‐Ling Dai, Qin Kuang, Yan‐Liang Li, Han Li, Jun‐Yan Liu, Lei Zou, Ran‐Ran Liang, Chu‐Feng Zhang, Juan Xu, Bo‐Chu Wang – 15 April 2022

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